Majeed Babar Muhammad Zafar, Haider S Sabahat, Mustafa Ghulam
Muhammad Zafar Majeed Babar, FCPS Medicine. Associate Professor of Medicine, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Punjab, Pakistan.
S.Sabahat Haider, FCPS Chemical Pathology. (name corrected) Assistant Professor, Senior Demonstrator, Department of Pathology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, Punjab, Pakistan.
Pak J Med Sci. 2016 Nov-Dec;32(6):1430-1433. doi: 10.12669/pjms.326.10714.
To see the role of Vitamin D supplementation on physical status of patients suffering from Congestive Heart Failure (dilated cardiomyopathy).
In this nonrandomized clinical trial, Forty three Patients with dilated cardiomyopathy who were not showing any significant improvements in physical performance on optimal treatment of heart failure were included. Vitamin D (200,000 IU) supplementation on weekly basis for a period of 12 weeks was added to heart failure treatment. And its effect was seen on 6 minutes' walk distance and Pro-BNP levels. SPSS version 19 was used for data analysis. Dependent sample t-test was used to see the significant effect of vitamin D supplementation on pre- intervention vitamin D levels, 6MWD and Pro-BNP. Taking p-value <0.05 as significant.
On clinical assessment most of the patients were in NYHA class II (65%), the percentages of NYHA Class I, III and IV was 19%, 9% and 7% respectively. The baseline mean vitamin D level of the study group was 16.59±3.54ng/ml and it raised to 31.97±3.64ng/ml after 12 weeks of supplementation with vitamin D, value<0.0005. The mean distance travelled by the study group before the intervention was 806±380ft while it increased to 945±393ft after the intervention, value of 0.008. The mean of pro-BNP level of the study group before the intervention was 1024±635 while it improved to 159±80 after the intervention with a significant value<0.0005.
Vitamin D supplementation decreases the severity of HF as reflected by reduction in serum pro-BNP levels and significant increase in six minutes' walk distance.
观察补充维生素D对充血性心力衰竭（扩张型心肌病）患者身体状况的作用。
在这项非随机临床试验中，纳入了43例扩张型心肌病患者，这些患者在心力衰竭的最佳治疗下身体机能未显示出任何显著改善。在心力衰竭治疗基础上，每周补充维生素D（200,000国际单位），为期12周。观察其对6分钟步行距离和脑钠肽前体（Pro-BNP）水平的影响。使用SPSS 19版进行数据分析。采用配对样本t检验来观察补充维生素D对干预前维生素D水平、6分钟步行距离（6MWD）和Pro-BNP的显著影响。以p值<0.05为有显著性差异。
临床评估显示，大多数患者处于纽约心脏病协会（NYHA）II级（65%），NYHA I级、III级和IV级的百分比分别为19%、9%和7%。研究组的基线平均维生素D水平为16.59±3.54纳克/毫升，补充维生素D 12周后升至31.97±3.64纳克/毫升，p值<0.0005。干预前研究组的平均步行距离为806±380英尺，干预后增至945±393英尺，p值为0.008。干预前研究组Pro-BNP水平的平均值为1024±635，干预后改善至159±80，p值显著<0.0005。
补充维生素D可降低心力衰竭的严重程度，这体现在血清Pro-BNP水平降低以及6分钟步行距离显著增加。
