Program in Medical Sciences, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand.
Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand.
Nutrients. 2017 Jul 26;9(8):799. doi: 10.3390/nu9080799.
(1) : Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D₂ supplementation on muscle strength and physical performance in knee OA patients; (2) : One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D₂ (ergocalciferol) per week for six months. Body composition, muscle strength, physical performance, serum 25(OH)D level, leptin, interlukin-6 (IL-6), parathyroid hormone (PTH), protein carbonyl, and metabolic profile were analyzed; (3) : Baseline mean serum 25(OH)D levels in knee OA patients was 20.73 ng/mL. Regarding baseline vitamin D status, 58.90% of patients had vitamin D insufficiency, and 41.10% had vitamin D deficiency. After vitamin D₂ supplementation for six months, mean serum 25(OH)D level was 32.14 ng/mL. For post-supplementation vitamin D status, 57.10% of patients had vitamin D sufficiency and 42.90% had vitamin D insufficiency. From baseline to six months, there was a significant increase in mean serum 25(OH)D level ( < 0.001), while mean LDL cholesterol ( = 0.001), protein carbonyl ( = 0.04), and PTH ( = 0.005) all significantly decreased. Patient quality of life (SF-12) and pain (visual analog scale, VAS) both improved significantly from baseline to the six-month time point ( = 0.005 and = 0.002, respectively). Knee OA patients demonstrated significant improvement grip strength and physical performance measurements after vitamin D₂ supplementation ( < 0.05); (4) : Vitamin D₂ supplementation for six months reduced oxidative protein damage, decreased pain (VAS), improved quality of life, and improved grip strength and physical performance in osteoarthritis patients.
(1) 血清 25-羟维生素 D（25(OH)D）水平较低在骨关节炎（OA）患者中很常见。然而，维生素 D 补充对肌肉力量和身体表现的影响仍不清楚。本研究将探讨维生素 D₂补充对膝骨关节炎患者肌肉力量和身体表现的影响； (2) 175 例血清 25(OH)D 水平较低（<30ng/ml）的原发性膝骨关节炎患者每周接受 40000IU 维生素 D₂（麦角钙化醇）治疗 6 个月。分析了身体成分、肌肉力量、身体表现、血清 25(OH)D 水平、瘦素、白细胞介素-6（IL-6）、甲状旁腺激素（PTH）、蛋白质羰基和代谢谱； (3) 膝骨关节炎患者的基线平均血清 25(OH)D 水平为 20.73ng/ml。关于基线维生素 D 状况，58.90%的患者存在维生素 D 不足，41.10%存在维生素 D 缺乏。维生素 D₂补充 6 个月后，平均血清 25(OH)D 水平为 32.14ng/ml。补充后维生素 D 状态，57.10%的患者维生素 D 充足，42.90%的患者维生素 D 不足。从基线到 6 个月，平均血清 25(OH)D 水平显著升高（<0.001），而平均 LDL 胆固醇（=0.001）、蛋白质羰基（=0.04）和 PTH（=0.005）均显著降低。患者的生活质量（SF-12）和疼痛（视觉模拟量表，VAS）从基线到 6 个月时均显著改善（=0.005 和=0.002，分别）。膝骨关节炎患者在维生素 D₂补充后握力和身体表现测量均有显著改善（<0.05）； (4) 维生素 D₂补充 6 个月可降低氧化蛋白损伤，减轻疼痛（VAS），改善生活质量，并改善骨关节炎患者的握力和身体表现。
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