Siddiqui M R, Sanford T, Nair A, Zerbe C S, Hughes M S, Folio L, Agarwal Piyush K, Brancato S J
Urologic Oncology Branch, National Cancer Institute, NIH, USA.
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, NIH, USA.
Urol Case Rep. 2017 Jan 10;11:37-38. doi: 10.1016/j.eucr.2016.12.002. eCollection 2017 Feb.
A 46-year old man with X-linked chronic granulomatous disease (CGD) being followed at the National Institute of Health with uncontrolled CGD colitis who developed chronic colovesical fistula, and end-stage renal disease (ESRD). Despite aggressive medical management of symptoms with immunomodulators and antibiotic prophylaxis, the chronic colovesical fistula led to chronic pyelonephritis, recurrent urinary tract infections, persistent air in the collecting system and bladder, and post-renal obstruction resulting in renal failure. Patient is now hemodialysis dependent and required diverting loop ileostomy placement. This report highlights multiple potential etiologies of rising serum creatinine in patients with CGD.
一名46岁患有X连锁慢性肉芽肿病（CGD）的男性患者，在国立卫生研究院接受随访，其CGD相关性结肠炎未得到控制，随后发展为慢性结肠膀胱瘘和终末期肾病（ESRD）。尽管使用免疫调节剂和抗生素预防措施对症状进行了积极的药物治疗，但慢性结肠膀胱瘘导致了慢性肾盂肾炎、复发性尿路感染、集合系统和膀胱内持续存在气体以及肾后梗阻，进而导致肾衰竭。患者目前依赖血液透析，并且需要进行回肠造口转流术。本报告强调了CGD患者血清肌酐升高的多种潜在病因。
