Cartabellotta F, Di Marco V
Unit of Internal Medicine, Buccheri La Ferla Hospital, Palermo, Italy.
Eur Rev Med Pharmacol Sci. 2016 Dec;20(1 Suppl):11-16.
Epidemiological studies report that in Sicily reside about 30,000 citizens with a diagnosis of chronic hepatitis due to HCV. The availability of direct antiviral action (DAA) is a real therapeutic breakthrough, but the high cost of the therapeutic regimes limits their use and forced the National Health System to establish clinical priority for the treatment.
The HCV Sicily Network is a web-based model of best medical practice, which was designed to improve the management and the treatment of HCV chronic hepatitis and cirrhosis. The network includes 41 centers and 84 gastroenterologists or infectivologists connected by a web platform that recorder the diagnosis and the clinic priority for the therapy.
From March 2015 to September 2016, 9,965 patients (57% male, mean age 61 years, 34% with age over 70 years) have been recorded in the web platform, 3,319 patients completed the treatment, and 1,754 completed the 12 weeks of follow-up. The Sustained Virological Response (SVR) was achieved in 1,541 patients (87.8%), while 136 patients (7.7%) 77 patients (4.5%) experienced a virological relapse during the 12 weeks of follow-up.
The HCV Sicily Network is an excellent system for the Regional Department of Health that can have a real estimation of patients that received an efficacy, but high-cost therapy.
流行病学研究报告称，西西里岛约有3万名被诊断为丙型肝炎病毒（HCV）所致慢性肝炎的公民。直接抗病毒药物（DAA）的出现是一项真正的治疗突破，但治疗方案的高昂成本限制了其使用，并迫使国家卫生系统确定治疗的临床优先级。
HCV西西里网络是一种基于网络的最佳医疗实践模式，旨在改善HCV慢性肝炎和肝硬化的管理与治疗。该网络包括41个中心和84名胃肠病学家或传染病专家，他们通过一个网络平台相连，该平台记录诊断和治疗的临床优先级。
2015年3月至2016年9月，9965名患者（57%为男性，平均年龄61岁，34%年龄超过70岁）被记录在网络平台上，3319名患者完成治疗，1754名患者完成了12周的随访。1541名患者（87.8%）实现了持续病毒学应答（SVR），而136名患者（7.7%）、77名患者（4.5%）在12周的随访期间出现病毒学复发。
HCV西西里网络对地区卫生部来说是一个出色的系统，它可以对接受了有效但成本高昂治疗的患者进行实际评估。
