Tarnowski Maciej, Malinowski Damian, Safranow Krzysztof, Dziedziejko Violetta, Pawlik Andrzej
a Department of Physiology , Pomeranian Medical University , Szczecin , Poland and.
b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
Gynecol Endocrinol. 2017 May;33(5):395-398. doi: 10.1080/09513590.2016.1276556. Epub 2017 Jan 13.
Gestational diabetes mellitus (GDM) is glucose intolerance detected during pregnancy. The MTNR1B gene is the genetic locus associated with type 2 diabetes, that may affect insulin secretion and pancreatic glucose sensing. In this study, we examined the association between MTNR1A (rs2119882) and MTNR1B (rs10830963, rs4753426) gene polymorphisms and the risk of GDM. According to the results of their oral glucose tolerance test (OGTT), the women were divided into two groups: 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). There were no statistically significant differences in the distribution of MTNR1A rs2119882 and MTNR1B rs4753426 genotypes and alleles between women with GDM and healthy pregnant women. With regard to the MTNR1B rs10830963 polymorphism, we observed a statistically significant prevalence of GG and CG genotypes and the G allele among pregnant women with GDM (GG + CG vs CC, OR 1.50, 95% CI 1.02-2.22, p = 0.04; G vs C, OR 1.43, 95% CI 1.07-1.90, p = 0.016). In a multivariate logistic regression analysis, a higher number of MTNR1B rs10830963 G alleles was an independent significant predictor of a higher risk of GDM. The results of our study indicate that MTNR1B rs10830963 polymorphism is associated with GDM susceptibility, and women with a higher number of G alleles have an increased risk of GDM development.
妊娠期糖尿病（GDM）是在孕期检测到的葡萄糖不耐受。MTNR1B基因是与2型糖尿病相关的基因位点，可能影响胰岛素分泌和胰腺葡萄糖感知。在本研究中，我们检测了MTNR1A（rs2119882）和MTNR1B（rs10830963、rs4753426）基因多态性与GDM风险之间的关联。根据口服葡萄糖耐量试验（OGTT）结果，将女性分为两组：204例患有GDM的孕妇和207例糖耐量正常（NGT）的孕妇。GDM孕妇与健康孕妇之间MTNR1A rs2119882和MTNR1B rs4753426基因型及等位基因的分布无统计学显著差异。关于MTNR1B rs10830963多态性，我们观察到GDM孕妇中GG和CG基因型以及G等位基因的患病率具有统计学显著性（GG + CG与CC相比，OR 1.50，95%CI 1.02 - 2.22，p = 0.04；G与C相比，OR 1.43，95%CI 1.07 - 1.90，p = 0.016）。在多因素逻辑回归分析中，MTNR1B rs10830963 G等位基因数量较多是GDM风险较高的独立显著预测因素。我们的研究结果表明，MTNR1B rs10830963多态性与GDM易感性相关，G等位基因数量较多的女性患GDM的风险增加。
