McKane Meghann, Soslow Jonathan H, Xu Meng, Saville Benjamin R, Slaughter James C, Burnette W Bryan, Markham Larry W
1 Thomas P. Graham Division of Pediatric Cardiology Monroe Carell Jr Children's Hospital at Vanderbilt University, Nashville, TN, USA.
2 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
J Child Neurol. 2017 Apr;32(5):499-504. doi: 10.1177/0883073816687422. Epub 2017 Jan 13.
Duchenne muscular dystrophy leads to cardiomyopathy. The objective of this study was to estimate the association of body mass index with cardiomyopathy onset. Cardiomyopathy was defined as left ventricular ejection fraction <55% or left ventricular fractional shortening <28%. Overall, 48% met the criteria for cardiomyopathy. We were unable to demonstrate an association between body mass index Z score and age of cardiomyopathy onset (hazard ratio 0.79, 95% confidence interval 0.57-1.11, P = .17) after adjusting for covariates. Duration of corticosteroid use ( P = .01), but not loss of ambulatory ability ( P = .47), was associated with age of cardiomyopathy onset. We were unable to detect a significant difference in median body mass index Z scores in corticosteroid-treated boys compared with corticosteroid-naïve boys (1.11, 95% confidence interval 0.25-1.95, vs 1.05, 95% confidence interval 0.01-1.86, P = .69). No association was detected between the body mass index Z scores of Duchenne muscular dystrophy subjects and age of cardiomyopathy onset.
杜氏肌营养不良会导致心肌病。本研究的目的是评估体重指数与心肌病发病之间的关联。心肌病定义为左心室射血分数<55%或左心室缩短分数<28%。总体而言，48%的患者符合心肌病标准。在对协变量进行调整后，我们未能证明体重指数Z评分与心肌病发病年龄之间存在关联（风险比0.79，95%置信区间0.57 - 1.11，P = 0.17）。使用皮质类固醇的时长（P = 0.01）与心肌病发病年龄相关，而丧失行走能力（P = 0.47）则与之无关。与未使用皮质类固醇的男孩相比，我们未能检测出使用皮质类固醇治疗的男孩在体重指数Z评分中位数上存在显著差异（分别为1.11，95%置信区间0.25 - 1.95，以及1.05，95%置信区间0.01 - 1.86，P = 0.69）。未检测到杜氏肌营养不良受试者的体重指数Z评分与心肌病发病年龄之间存在关联。
