Fukuda Makoto, Yoshimura Kengo, Namekawa Koki, Sakai Kiyotaka
Department of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa, Wakayama, 649-6493, Japan.
Department of Medical Engineering, Junshin Gakuen University, Fukuoka, Japan.
J Artif Organs. 2017 Jun;20(2):145-151. doi: 10.1007/s10047-016-0942-5. Epub 2017 Jan 13.
The objective of the present study is to evaluate the effect of filtration coefficient and internal filtration on dialysis fluid flow and mass transfer coefficient in dialyzers using dimensionless mass transfer correlation equations. Aqueous solution of vitamin B clearances were obtained for REXEED-15L as a low flux dialyzer, and APS-15EA and APS-15UA as high flux dialyzers. All the other design specifications were identical for these dialyzers except for filtration coefficient. The overall mass transfer coefficient was calculated, moreover, the exponents of Reynolds number (Re) and film mass transfer coefficient of the dialysis-side fluid (k ) for each flow rate were derived from the Wilson plot and dimensionless correlation equation. The exponents of Re were 0.4 for the low flux dialyzer whereas 0.5 for the high flux dialyzers. Dialysis fluid of the low flux dialyzer was close to laminar flow because of its low filtration coefficient. On the other hand, dialysis fluid of the high flux dialyzers was assumed to be orthogonal flow. Higher filtration coefficient was associated with higher k influenced by mass transfer rate through diffusion and internal filtration. Higher filtration coefficient of dialyzers and internal filtration affect orthogonal flow of dialysis fluid.
本研究的目的是使用无量纲传质相关方程，评估滤过系数和内部滤过对透析器中透析液流量和传质系数的影响。以REXEED - 15L作为低通量透析器，APS - 15EA和APS - 15UA作为高通量透析器，获得了维生素B水溶液的清除率。除滤过系数外，这些透析器的所有其他设计规格均相同。此外，计算了总传质系数，并从威尔逊图和无量纲相关方程中得出了每种流速下雷诺数（Re）和透析侧流体膜传质系数（k）的指数。低通量透析器的Re指数为0.4，而高通量透析器的Re指数为0.5。由于其低滤过系数，低通量透析器的透析液接近层流。另一方面，高通量透析器的透析液被假定为正交流。较高的滤过系数与受扩散和内部滤过传质速率影响的较高k相关。透析器较高的滤过系数和内部滤过会影响透析液的正交流。
