乳腺癌患者的血清骨钙素水平。
Serum osteocalcin levels in breast cancer patients.
作者信息
Pietschmann P, Zielinski C, Woloszczuk W
机构信息
Department of Medicine II, University of Vienna, Austria.
出版信息
J Cancer Res Clin Oncol. 1989;115(5):456-8. doi: 10.1007/BF00393337.
The serum levels of osteocalcin, a 49-amino-acid bone-matrix protein, which is a biochemical parameter of bone formation, were measured in 61 patients with breast cancer. Breast cancer patients were subdivided as follows: (a) Patients in complete remission; (b) patients with visceral metastases (without bone metastases); (c) patients with bone metastases (with or without visceral metastases). Serum osteocalcin levels were significantly higher in patients with bone metastases than in patients in complete remission (P less than 0.005). When osteocalcin levels of patients with bone metastases were compared with those of an age-matched control group, serum osteocalcin levels were higher in the patients with bone metastases; however, the differences did not reach statistical significance. Serum osteocalcin levels of patients with visceral metastases (without bone metastases) were significantly lower than in control subjects (P less than 0.02). Our data demonstrate that serum osteocalcin levels are higher in breast cancer patients with bone metastases than in patients in remission. Bone formation, as reflected by serum osteocalcin levels, is decreased in breast cancer patients with visceral metastases.
对61例乳腺癌患者测定了骨钙素（一种由49个氨基酸组成的骨基质蛋白，是骨形成的生化指标）的血清水平。乳腺癌患者被分为以下几类：（a）完全缓解的患者；（b）有内脏转移（无骨转移）的患者；（c）有骨转移（有或无内脏转移）的患者。有骨转移患者的血清骨钙素水平显著高于完全缓解的患者（P<0.005）。当将有骨转移患者的骨钙素水平与年龄匹配的对照组进行比较时，有骨转移患者的血清骨钙素水平更高；然而，差异未达到统计学意义。有内脏转移（无骨转移）患者的血清骨钙素水平显著低于对照组（P<0.02）。我们的数据表明，有骨转移的乳腺癌患者的血清骨钙素水平高于缓解期患者。有内脏转移的乳腺癌患者中，血清骨钙素水平所反映的骨形成减少。
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