Liu Deng-Rui, Guan Quan-Lin, Gao Ming-Tai, Jiang Lei, Kang Hong-Xia
Department of Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province - PR China.
Int J Biol Markers. 2017 Jul 24;32(3):e278-e283. doi: 10.5301/jbm.5000244.
The mannose receptor is an immune adhesion molecule mainly expressed on the surface of antigen-presenting cells such as nonmature dendritic cells and macrophages. This study aimed to investigate mannose receptor expression and its predictive role in papillary gastric cancer patients.
The expression of the mannose receptor was measured in 120 samples of gastric cancer tissues and corresponding paracarcinoma tissues, by immunohistochemical and quantitative real-time PCR analysis. The relationships between mannose receptor expression and clinicopathological features of gastric cancer patients were analyzed.
The expression rate of the mannose receptor in gastric cancer cells was 45.8% (54/120), significantly higher than that in the paracarcinoma tissue (20.0%, 36/120) (χ2 = 6.286, p = 0.012). High expression of the mannose receptor was closely related to tumor size, T stage, N stage and Union for International Cancer Control (UICC) stage of gastric cancer (p<0.05). A Kaplan-Meier survival model indicated that the survival of patients in the high-expression mannose receptor group was significantly shorter than in the low-expression mannose receptor group (p<0.05). Cox regression analysis showed that high mannose receptor expression was an independent predictor for the prognosis of patients with gastric cancer.
High mannose receptor expression indicates poor prognosis for gastric cancer patients. The mannose receptor may be an important molecular marker for gastric cancer prognosis.
甘露糖受体是一种免疫粘附分子，主要表达于未成熟树突状细胞和巨噬细胞等抗原呈递细胞表面。本研究旨在探讨甘露糖受体在胃乳头状癌患者中的表达及其预测作用。
采用免疫组织化学和定量实时聚合酶链反应分析方法，检测120例胃癌组织及相应癌旁组织样本中甘露糖受体的表达情况。分析甘露糖受体表达与胃癌患者临床病理特征之间的关系。
胃癌细胞中甘露糖受体的表达率为45.8%（54/120），显著高于癌旁组织（20.0%，36/120）（χ2 = 6.286，p = 0.012）。甘露糖受体高表达与胃癌的肿瘤大小、T分期、N分期及国际癌症控制联盟（UICC）分期密切相关（p<0.05）。Kaplan-Meier生存模型显示，甘露糖受体高表达组患者的生存期显著短于低表达组（p<0.05）。Cox回归分析表明，甘露糖受体高表达是胃癌患者预后的独立预测因子。
甘露糖受体高表达提示胃癌患者预后不良。甘露糖受体可能是胃癌预后的重要分子标志物。
