Fiala Mark A, Wildes Tanya M
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
George Warren Brown School of Social Work, Washington University, St. Louis, Missouri.
Cancer. 2017 May 1;123(9):1590-1596. doi: 10.1002/cncr.30526. Epub 2017 Jan 13.
Recent treatment advances have greatly improved the prognosis of patients with multiple myeloma. However, some of these newer, more effective treatments are intensive and expensive and their use remains low, particularly among black patients.
In the current study, the authors reviewed the use patterns of stem cell transplantation and bortezomib using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database.
After controlling for overall health and potential access barriers, black patients were found to be 37% (P<.0001) less likely to undergo stem cell transplantation, and 21% (P<.0001) less likely to be treated with bortezomib. Moreover, the authors found that the underuse of these treatments was associated with a 12% increase in the hazard ratio for death among black patients (P = 0.0007).
Eliminating health disparities, a current focus of US public policy, is highly complex, as illustrated by the results of the current study. In patients with multiple myeloma, treatment disparities are not completely explained by potential access barriers. Additional factors, such as structural barriers in the health care system and individual decision making among black and white patients, must be explored to fully explain the disparity. Cancer 2017;123:1590-1596. © 2017 American Cancer Society.
近期的治疗进展极大地改善了多发性骨髓瘤患者的预后。然而,其中一些更新、更有效的治疗方法强度大且费用高,其使用率仍然很低,尤其是在黑人患者中。
在本研究中,作者使用监测、流行病学和最终结果(SEER)-医疗保险链接数据库回顾了干细胞移植和硼替佐米的使用模式。
在控制了总体健康状况和潜在的获取障碍后,发现黑人患者接受干细胞移植的可能性降低了37%(P<0.0001),接受硼替佐米治疗的可能性降低了21%(P<0.0001)。此外,作者发现这些治疗方法的使用不足与黑人患者死亡风险比增加12%相关(P = 0.0007)。
消除健康差异是美国当前公共政策的重点,但正如本研究结果所示,这极具复杂性。在多发性骨髓瘤患者中,治疗差异不能完全由潜在的获取障碍来解释。必须探索其他因素,如医疗保健系统中的结构性障碍以及黑人和白人患者的个人决策,以充分解释这种差异。《癌症》2017年;123:1590 - 1596。©2017美国癌症协会。