Iliaz Sinem, Tanriverdio Elif, Chousein Efsun Gonca Ugur, Ozturk Sakine, Iliaz Raim, Cetinkaya Erdogan, Caglar Emel
Department of Pulmonary Medicine, Koc University Hospital, Istanbul, Turkey.
Department of Pulmonary Medicine, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
Clin Respir J. 2018 Mar;12(3):961-965. doi: 10.1111/crj.12612. Epub 2017 Jan 31.
Recent articles revealed that an increased main pulmonary artery to ascending aorta ratio (PA/A) in thorax computed tomography (CT) correlated with pulmonary hypertension, and might be linked to a high probability of chronic obstructive pulmonary disease (COPD) exacerbations.
In this study, our aim was to evaluate the clinical importance of PA/A in patients with exacerbations of COPD and investigate its relationship with the number of exacerbations in 1 year or short/long-term mortality after hospital discharge.
One hundred fifty-six patients hospitalized for COPD exacerbations who fulfilled our inclusion criteria were enrolled in the study. We recorded the number of exacerbations in 1 year from hospital records, checked mortality status, and calculated the PA/A ratio from thorax CT images.
PA/A ratio positively correlated with the number of hospitalizations for COPD exacerbations and the total number of exacerbations (hospitalized or not) in 1 year, and baseline PaCO level during hospitalization (r = 0.376, P < 0.001, r = 0.230, P = 0.004, and r = 0.328, P < 0.001, respectively). There was no relationship between mortality and PA/A.
Our study showed that PA/A was related with the number of hospitalizations and the total number of exacerbations due to COPD in 1 year. However, there was no relationship between PA/A and mortality.
近期文章显示，胸部计算机断层扫描（CT）中主肺动脉与升主动脉比值（PA/A）升高与肺动脉高压相关，且可能与慢性阻塞性肺疾病（COPD）加重的高概率有关。
在本研究中，我们的目的是评估PA/A在COPD加重患者中的临床重要性，并研究其与1年内加重次数或出院后短期/长期死亡率的关系。
纳入156例因COPD加重住院且符合我们纳入标准的患者。我们从医院记录中记录1年内的加重次数，检查死亡率状况，并从胸部CT图像计算PA/A比值。
PA/A比值与COPD加重的住院次数、1年内加重的总次数（无论是否住院）以及住院期间的基线PaCO水平呈正相关（r分别为0.376，P < 0.001；r为0.230，P = 0.004；r为0.328，P < 0.001）。死亡率与PA/A之间无关联。
我们的研究表明，PA/A与1年内因COPD导致的住院次数和加重总次数有关。然而，PA/A与死亡率之间无关联。
