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[小肠原发性溃疡]

[Primary ulcerations of the small intestine].

作者信息

Marsepoil T, Caban J, Levesque P, Bertaux M, Blin F

机构信息

Service de Réanimation Polyvalente, Hôpital de Gonesse.

出版信息

J Chir (Paris). 1989 Aug-Sep;126(8-9):463-5.

PMID:2808561
Abstract

The authors report a recent case of primary ulceration of the small intestine revealed by spontaneous perforation. This is a rare condition with a non specific semiology which only exceptionally permits diagnosis before complications occur. The latter are dominated by perforation, gastrointestinal hemorrhage and a sub-acute obstructive syndrome. The lesion, generally single, is found on the anti-mesenteric border of the jejunum or terminal ileum on a short only slightly inflammed segment and pathological examination does not reveal any specific process. Treatment is surgical. It confirms the diagnosis and enables a segmentary resection or simple suture to be carried out. The condition does not recur. A complete etiological investigation is required to exclude other causes of small intestinal ulceration before its "spontaneous" nature may be inferred. Infectious and vascular theories are most often proposed among the pathophysiological hypotheses. Far from being exclusive, these theories may interact and enable a coherent multi-factorial mechanism to be proposed as to the origin of the ulceration (regardless of its initial cause). Spontaneous ulcers are therefore included in a wider nosological classification ranging from stress ulcer to necrosing enteritis.

摘要

作者报告了一例因自发性穿孔而发现的原发性小肠溃疡近期病例。这是一种罕见疾病,其症状不具特异性,只有在极少数情况下才能在并发症出现之前作出诊断。并发症主要包括穿孔、胃肠道出血和亚急性梗阻综合征。病变通常为单发,位于空肠或回肠末端的系膜对侧缘,累及较短的仅轻度炎症的肠段,病理检查未发现任何特异性病变。治疗方法为手术治疗。手术可确诊并能进行节段性切除或单纯缝合。该病不会复发。在推断其“自发性”性质之前,需要进行全面的病因学调查以排除小肠溃疡的其他病因。在病理生理假说中,感染和血管学说最为常见。这些学说并非相互排斥,它们可能相互作用,从而提出一个关于溃疡形成原因的连贯的多因素机制(无论其初始病因如何)。因此,自发性溃疡被纳入一个更广泛的疾病分类中,范围从应激性溃疡到坏死性肠炎。

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