儿童体内的总体脂肪、腹部脂肪、体脂分布以及与脂肪细胞脂肪酸结合蛋白（FABP4）相关的健康替代指标。
Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children.
作者信息
Dencker Magnus, Danielson Anton, Karlsson Magnus K, Wollmer Per, Andersen Lars B, Thorsson Ola
机构信息
Department of Translational Medicine, Unit of Medical Imaging and Physiology, Skåne University Hospital, Lund University, Lund.
Department of Clinical Sciences, Clinical and Molecular Osteoporosis Research Unit, Skåne University Hospital, Lund University, Lund.
出版信息
J Pediatr Endocrinol Metab. 2017 Apr 1;30(4):375-382. doi: 10.1515/jpem-2016-0278.
BACKGROUND
The aim of the study was to assess possible relationships between adipocyte fatty acid-binding protein (FABP4) and total body fat (TBF), abdominal fat, body fat distribution, aerobic fitness, blood pressure, cardiac dimensions and the increase in body fat over 2 years in a community sample of children.
METHODS
A cross-sectional study was used in a community sample of 170 (92 boys and 78 girls) children aged 8-11 years. TBF and abdominal fat (AFM) were measured by dual-energy X-ray absorptiometry (DXA). TBF was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK) was assessed by indirect calorimetry during a maximal exercise test and scaled to body mass. Systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial (LA) size was measured, and left ventricular mass (LVM) was calculated. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for FABP4.
RESULTS
Partial correlations, with adjustment for sex, between FABP4 vs. ln TBF, ln BF%, ln AFM, AFM/TBF and VO2PEAK were (r=0.69, 0.68, 0.69, 0.49 and -0.39, p<0.05 for all). Moreover, SBP, PP, LVM and LA were also weakly correlated with FABP4 (r=0.23, 0.22, 0.28 and 0.21, p<0.05 for all). Correlations between FABP4 vs. increase in TBF and AFM over 2 years were 0.29 and 0.26, p<0.05, for both. (Increase in percent body fat or change in fat distribution were not correlated.) Conclusions: Findings from this community-based cohort of young children show that increased body fat and abdominal fat, more abdominal body fat distribution, low fitness, more LVM and increased LA, increased SBP and PP were all associated with increased levels of FABP4. Increase in TBF and abdominal fat over 2 years were also associated with increased levels of FABP4.
背景
本研究旨在评估在儿童社区样本中，脂肪细胞脂肪酸结合蛋白（FABP4）与全身脂肪（TBF）、腹部脂肪、身体脂肪分布、有氧适能、血压、心脏大小以及两年内身体脂肪增加之间可能存在的关系。
方法
对170名（92名男孩和78名女孩）8至11岁的儿童社区样本进行了横断面研究。通过双能X线吸收法（DXA）测量TBF和腹部脂肪（AFM）。TBF也表示为总体重的百分比（BF%），身体脂肪分布计算为AFM/TBF。在最大运动试验期间通过间接量热法评估最大摄氧量（VO2PEAK），并根据体重进行标化。测量收缩压和舒张压（SBP和DBP）以及脉压（PP）。进行了超声心动图检查。测量左心房（LA）大小，并计算左心室质量（LVM）。152名儿童（84名男孩和68名女孩）可进行随访DXA扫描。对冷冻血清样本进行FABP4分析。
结果
在对性别进行校正后，FABP4与ln TBF、ln BF%、ln AFM、AFM/TBF和VO2PEAK之间的偏相关系数分别为（r = 0.69、0.68、0.69、0.49和 -0.39，均p<0.05）。此外，SBP、PP、LVM和LA与FABP4也呈弱相关（r = 0.23、0.22、0.28和0.21，均p<0.05）。FABP4与两年内TBF和AFM增加之间的相关系数分别为0.29和0.26，均p<0.05。（身体脂肪百分比增加或脂肪分布变化无相关性。）结论：该基于社区的幼儿队列研究结果表明，身体脂肪和腹部脂肪增加、腹部身体脂肪分布更多、适能较低、LVM和LA增加、SBP和PP升高均与FABP4水平升高相关。两年内TBF和腹部脂肪增加也与FABP4水平升高相关。
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