McNerney Kevin O, Vasquez Juan C, Kent Michael W, McNamara Joseph M
Departments of *Pediatrics †Hematology and Oncology, Yale New Haven Hospital, New Haven, CT.
J Pediatr Hematol Oncol. 2017 Nov;39(8):e454-e455. doi: 10.1097/MPH.0000000000000776.
We report a case of a child with pre-B cell acute lymphoblastic leukemia undergoing maintenance chemotherapy with 6-mercaptopurine and methotrexate (MTX) who developed sinusoidal obstruction syndrome after being treated with ciprofloxacin for BK viremia. This case represents a rare complication of maintenance therapy with MTX and 6-mercaptopurine, and suggests a drug interaction between ciprofloxacin and MTX.
我们报告了一例前体B细胞急性淋巴细胞白血病患儿，该患儿正在接受6-巯基嘌呤和甲氨蝶呤（MTX）的维持化疗，在因BK病毒血症接受环丙沙星治疗后发生了肝窦阻塞综合征。该病例代表了MTX和6-巯基嘌呤维持治疗的一种罕见并发症，并提示环丙沙星与MTX之间存在药物相互作用。
