Ahmadi Majid, Gharibi Tohid, Dolati Sanam, Rostamzadeh Davood, Aslani Saeed, Baradaran Behzad, Younesi Vahid, Yousefi Mehdi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2017 Mar;87:596-608. doi: 10.1016/j.biopha.2016.12.072. Epub 2017 Jan 10.
Recent genome-wide association studies have documented a number of genetic variants to explain mechanisms underlying autoimmune diseases. However, the precise etiology of autoimmune diseases remains largely unknown. Epigenetic mechanisms like alterations in the post-translational modification of histones and DNA methylation may potentially cause a breakdown of immune tolerance and the perpetuation of autoreactive responses. Recently, several studies both in experimental models and clinical settings proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically, data support the impact of epigenetic changes in autoimmune diseases, in some cases based on mechanistical observations. Epigenetic therapy already being employed in hematopoietic malignancies may also be associated with beneficial effects in autoimmune diseases. In this review, we will discuss on what we know and expect about the treatment of autoimmune disease based on epigenetic aberrations.
近期的全基因组关联研究已经记录了许多基因变异，以解释自身免疫性疾病背后的机制。然而，自身免疫性疾病的确切病因在很大程度上仍然未知。表观遗传机制，如组蛋白翻译后修饰的改变和DNA甲基化，可能会导致免疫耐受的破坏和自身反应性反应的持续存在。最近，一些在实验模型和临床环境中的研究表明，表观基因组可能是更好地理解自身免疫性疾病起始和持续存在的关键。更具体地说，数据支持表观遗传变化在自身免疫性疾病中的影响，在某些情况下是基于机制观察。已经用于血液系统恶性肿瘤的表观遗传疗法也可能对自身免疫性疾病有有益影响。在这篇综述中，我们将讨论基于表观遗传异常对自身免疫性疾病治疗的已知情况和期望。
