Parkinson's disease: no NOP, new hope.
作者信息
Arcuri Ludovico, Mercatelli Daniela, Morari Michele
机构信息
Department of Medical Sciences, Section of Pharmacology, and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy.
出版信息
Oncotarget. 2017 Feb 7;8(6):8995-8996. doi: 10.18632/oncotarget.13710.
Abstract
摘要
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Parkinson's disease: no NOP, new hope.帕金森病：没有孤啡肽原，却有新希望。
Oncotarget. 2017 Feb 7;8(6):8995-8996. doi: 10.18632/oncotarget.13710.
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Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson's disease: a behavioral and neurochemical study in reserpinized mice.进一步的证据表明孤啡肽在帕金森病的病理生理学中起作用：利血平化小鼠的行为和神经化学研究。
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C-Terminal glycine is crucial for hyperalgesic activity of nociceptin/orphanin FQ-(1-6).
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Nociceptin/orphanin FQ prevents the antinociceptive action of paracetamol on the rat hot plate test.孤啡肽/痛敏肽可阻断对乙酰氨基酚在大鼠热板试验中的镇痛作用。
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Plasma nociceptin/orphanin FQ levels in response to the hyperventilation test in healthy subjects.健康受试者对过度通气试验的血浆孤啡肽/孤啡肽 FQ 水平反应。
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Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice.孤啡肽/痛敏肽（ORL1受体激动剂）对糖尿病小鼠的镇痛作用
Eur J Pharmacol. 1999 Apr 9;370(2):109-16. doi: 10.1016/s0014-2999(99)00112-0.
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Managing Parkinson's disease: moving ON with NOP.管理帕金森病：与 NOP 一起前行。
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Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic.孤啡肽/强啡肽 FQ 受体配体及转化难题：聚焦塞来昔布作为新型镇痛药。
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本文引用的文献
1
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.孤啡肽/痛敏肽受体的结构、信号传导、配体、功能以及与阿片系统的相互作用
Pharmacol Rev. 2016 Apr;68(2):419-57. doi: 10.1124/pr.114.009209. Epub 2016 Mar 8.
2
Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease.基因和药理学证据表明内源性孤啡肽/孤啡肽FQ促成帕金森病中多巴胺能细胞的损失。
Neurobiol Dis. 2016 May;89:55-64. doi: 10.1016/j.nbd.2016.01.016. Epub 2016 Jan 22.
3
Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.孤啡肽/强啡肽抑制中脑多巴胺能神经元通过 p38-MAPK 依赖机制的存活和轴突生长。
Mol Neurobiol. 2016 Dec;53(10):7284-7297. doi: 10.1007/s12035-015-9611-6. Epub 2015 Dec 21.
4
Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.新型孤啡肽/强啡肽 FQ 受体拮抗剂 NiK-21273 与 SB-612111 比较的抗帕金森病急性和慢性作用。
Br J Pharmacol. 2013 Feb;168(4):863-79. doi: 10.1111/j.1476-5381.2012.02219.x.
5
Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease.帕金森病患者脑中的神经激肽/孤啡肽水平升高。
Mov Disord. 2010 Aug 15;25(11):1723-32. doi: 10.1002/mds.23271.
6
The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.新型伤害感受素/孤啡肽FQ受体拮抗剂Trap-101通过抑制黑质-丘脑通路减轻实验性帕金森病：与左旋多巴的积极相互作用。
J Neurochem. 2008 Dec;107(6):1683-96. doi: 10.1111/j.1471-4159.2008.05735.x. Epub 2008 Nov 5.
7
Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.孤啡肽/孤啡肽FQ传递的阻断减轻与帕金森病相关的症状和神经退行性变。
J Neurosci. 2005 Oct 19;25(42):9591-601. doi: 10.1523/JNEUROSCI.2546-05.2005.
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Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release.阻断大鼠黑质中孤啡肽/孤啡肽FQ的传递可逆转氟哌啶醇诱导的运动不能，并使黑质谷氨酸释放恢复正常。
J Neurochem. 2004 Dec;91(6):1501-4. doi: 10.1111/j.1471-4159.2004.02843.x.
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