Böttner K, Mussinghoff P, Meyer Zur Hörste M, Heinz C, Heiligenhaus A
Uveitis-Zentrum, Augenärzte am St. Franziskus Hospital, Münster.
Klin Monbl Augenheilkd. 2017 Sep;234(9):1174-1178. doi: 10.1055/s-0042-120276. Epub 2017 Jan 13.
Chronic illness - such as uveitis - may lead to socio-economic consequences, and poorer quality of life. To study the influence of uveitis on quality of life and professional development. Prospective evaluation of juvenile patients with uveitis (age < 18 years, classification of uveitis as in Standardization of Uveitis Nomenclature [SUN] criteria, duration of disease ≥ 12 months) seen in a tertiary referral centre. Influence of uveitis on quality of life, recreational activities, educational training and development of severe disability were analysed. Results were correlated to clinical data, and analysed by descriptive statistics. 39 patients of 49 (80 %) had anterior uveitis (69.4 % in both eyes), of which 34 (69 %) presented with associated systemic disease (juvenile idiopathic arthritis, n = 28). 33 (80 %) had developed complications caused by uveitis. 15 patients (31 %) had undergone ophthalmic surgery due to these complications. Many patients were treated with conventional (n = 37; 76 %) and biological (n = 18; 37 %) disease-modifying antirheumatic drugs (DMARDs). In 41 % of the cases, quality of life and recreational time (23 %) were markedly reduced. Sick leave from pre-school or school because of uveitis (mean 12.5 days/year; 15 % > 20 days) was recorded in 32 patients (65 %). Uveitis negatively influenced school education in 29 %, and resulted in the necessity to repeat class (n = 3) or to change school (n = 3). Severe disability due to uveitis was found in 30 % of the patients. Uveitis in childhood and adolescence may have a substantial impact on social and professional perspectives. Uveitis may result in severe disability even in early childhood.
慢性病——如葡萄膜炎——可能导致社会经济后果以及生活质量下降。为研究葡萄膜炎对生活质量和职业发展的影响。对在一家三级转诊中心就诊的葡萄膜炎青少年患者（年龄<18岁，葡萄膜炎分类符合葡萄膜炎命名标准化[SUN]标准，病程≥12个月）进行前瞻性评估。分析了葡萄膜炎对生活质量、娱乐活动、教育培训以及严重残疾发展的影响。结果与临床数据相关，并通过描述性统计进行分析。49例患者中有39例（80%）患有前葡萄膜炎（双眼患病占69.4%），其中34例（69%）伴有相关全身性疾病（青少年特发性关节炎，n = 28）。33例（80%）出现了由葡萄膜炎引起的并发症。15例患者（31%）因这些并发症接受了眼科手术。许多患者接受了传统（n = 37；76%）和生物（n = 18；37%）改善病情抗风湿药物（DMARDs）治疗。在41%的病例中，生活质量和娱乐时间（23%）显著降低。32例患者（65%）记录了因葡萄膜炎导致的学前或学校病假（平均每年12.5天；15%超过20天）。葡萄膜炎对29%的学校教育产生了负面影响，导致有必要留级（n = 3）或转学（n = 3）。30%的患者出现了因葡萄膜炎导致的严重残疾。儿童和青少年时期的葡萄膜炎可能对社会和职业前景产生重大影响。葡萄膜炎甚至在幼儿期也可能导致严重残疾。
