Thomsen Barbara Blicher, Gredal Hanne, Wirenfeldt Martin, Kristensen Bjarne Winther, Clausen Bettina Hjelm, Larsen Anders Elm, Finsen Bente, Berendt Mette, Lambertsen Kate Lykke
Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg, Denmark.
Department of Pathology, Odense University Hospital, 5000, Odense, Denmark.
Acta Vet Scand. 2017 Jan 13;59(1):7. doi: 10.1186/s13028-016-0275-7.
Dogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with ischaemic stroke constitute an opportunity to study the neuropathology of ischaemic stroke in an animal species.
A 7 years and 8 months old female neutered Rottweiler dog suffered a middle cerebral artery infarct and was euthanized 3 days after onset of neurological signs. The brain was subjected to histopathology and immunohistochemistry. Neuropathological changes were characterised by a pan-necrotic infarct surrounded by peri-infarct injured neurons and reactive microglia/macrophages and astrocytes.
The neuropathological changes reported in the present study were similar to findings in human patients with ischaemic stroke. The dog with spontaneous ischaemic stroke is of interest as a complementary spontaneous animal model for further neuropathological studies.
犬类会发生自发性缺血性中风，其临床表现与人类缺血性中风患者极为相似。虽然已经建立了动物中风模型，但事实证明，将从此类模型中获得的结果转化为针对人类中风患者的成功治疗策略并非易事。为了弥补中风研究中这一明显的转化差距，患有缺血性中风的犬类为研究动物物种缺血性中风的神经病理学提供了一个契机。
一只7岁8个月大的雌性绝育罗威纳犬发生了大脑中动脉梗死，并在出现神经症状3天后实施安乐死。对其大脑进行了组织病理学和免疫组织化学检查。神经病理学变化的特征是出现全坏死性梗死，周围伴有梗死灶周围受损神经元以及反应性小胶质细胞/巨噬细胞和星形胶质细胞。
本研究报告的神经病理学变化与人类缺血性中风患者的发现相似。患有自发性缺血性中风的犬类作为进一步神经病理学研究的补充性自发动物模型具有重要意义。
