Braun Ueli, Malbon Alexandra, Kochan Manon, Riond Barbara, Janett Fredi, Iten Cornelia, Dennler Matthias
Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Acta Vet Scand. 2017 Jan 13;59(1):8. doi: 10.1186/s13028-017-0276-1.
In cattle, the prognosis of brain abscess is unfavourable and treatment is therefore not recommended. To the knowledge of the authors, there has been no report of successful treatment of a brain abscess in cattle.This report describes the clinical, computed tomographic and postmortem findings in a Holstein-Friesian bull with a hypophyseal abscess.
The main clinical findings were generalised ataxia, ptyalism, prolapse of the tongue, dropped jaw, dysphagia, head tilt and unilateral ptosis. Cerebrospinal fluid evaluation revealed 2437 leukocytes/µl and severe pleocytosis. CT examination of the head showed a cavitary lesion consistent with an abscess in the hypophysis. Treatment consisted of gentamicin and flunixin meglumine for 3 days and amoxicillin for 40 days. The neurological signs resolved within 8 days of the start of treatment. The bull was slaughtered 11 months later because of infertility, and a postmortem examination was carried out. Histologically, a mild chronic non suppurative meningoencephalitis restricted to the ventral diencephalon was diagnosed. In addition, there was mild to moderate multifocal chronic lymphoplasmacytic hypophysitis with mild multifocal fibrosis.
This case report stresses the significance of CT in confirming the clinical and laboratory diagnosis of central nervous system disorders in cattle and for localising brain lesions. Treatment of the brain abscess resulted, with respect to the central nervous disorder, in a successful outcome and was encouraging considering that most cases have an unfavourable prognosis.
在牛群中，脑脓肿的预后不佳，因此不建议进行治疗。据作者所知，尚无牛脑脓肿成功治疗的报告。本报告描述了一头患有垂体脓肿的荷斯坦-弗里生公牛的临床、计算机断层扫描和尸检结果。
主要临床症状为全身性共济失调、流涎、舌脱垂、下颌下垂、吞咽困难、头部倾斜和单侧上睑下垂。脑脊液评估显示每微升有2437个白细胞，且有严重的细胞增多现象。头部CT检查显示有一个空洞性病变，与垂体脓肿相符。治疗包括使用庆大霉素和氟尼辛葡甲胺3天，阿莫西林40天。治疗开始后8天内神经症状消失。11个月后，由于不育，这头公牛被屠宰并进行了尸检。组织学检查诊断为轻度慢性非化脓性脑膜脑炎，局限于腹侧间脑。此外，还有轻度至中度多灶性慢性淋巴细胞浆细胞性垂体炎，并伴有轻度多灶性纤维化。
本病例报告强调了CT在确认牛中枢神经系统疾病的临床和实验室诊断以及定位脑部病变方面的重要性。就中枢神经系统疾病而言，脑脓肿的治疗取得了成功，鉴于大多数病例预后不佳，这一结果令人鼓舞。
