磨牙症的治疗：系统评价与网状Meta分析（方案）
Therapies for bruxism: a systematic review and network meta-analysis (protocol).
作者信息
Mesko Mauro Elias, Hutton Brian, Skupien Jovito Adiel, Sarkis-Onofre Rafael, Moher David, Pereira-Cenci Tatiana
机构信息
Graduate Program in Dentistry, Federal University of Pelotas, Rua Gonçalves Chaves, 457, 5th floor, Pelotas, RS, Brazil.
Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, General Campus, 501 Smyth Rd, Ottawa, ON, K1H8L6, Canada.
出版信息
Syst Rev. 2017 Jan 13;6(1):4. doi: 10.1186/s13643-016-0397-z.
BACKGROUND
Bruxism is a sleep disorder characterized by grinding and clenching of the teeth that may be related to irreversible tooth injuries. It is a prevalent condition occurring in up to 31% of adults. However, there is no definitive answer as to which of the many currently available treatments (including drug therapy, intramuscular injections, physiotherapy, biofeedback, kinesiotherapy, use of intraoral devices, or psychological therapy) is the best for the clinical management of the different manifestations of bruxism. The aim of this systematic review and network meta-analysis is to answer the following question: what is the best treatment for adult bruxists?
METHODS/DESIGN: Comprehensive searches of the Cochrane Library, MEDLINE (via PubMed), Scopus, and LILACS will be completed using the following keywords: bruxism and therapies and related entry terms. Studies will be included, according to the eligibility criteria (Controlled Clinical Trials and Randomized Clinical Trials, considering specific outcome measures for bruxism). The reference lists of included studies will be hand searched. Relevant data will be extracted from included studies using a specially designed data extraction sheet. Risk of bias of the included studies will be assessed, and the overall strength of the evidence will be summarized (i.e., GRADE). A random effects model will be used for all pairwise meta-analyses (with a 95% confidence interval). A Bayesian network meta-analysis will explore the relative benefits between the various treatments. The review will be reported using the Preferred Reporting Items for Systematic Reviews incorporating Network Meta-Analyses (PRISMA-NMA) statement.
DISCUSSION
This systematic review aims at identifying and evaluating therapies to treat bruxism. This systematic review may lead to several recommendations, for both patients and researchers, as which is the best therapy for a specific patient case and how future studies need to be designed, considering what is available now and what is the reality of the patient.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42015023308.
背景
磨牙症是一种睡眠障碍，其特征为牙齿磨动和紧咬，可能导致不可逆的牙齿损伤。这是一种普遍存在的病症，在高达31%的成年人中出现。然而，对于目前众多可用治疗方法（包括药物治疗、肌肉注射、物理治疗、生物反馈、运动疗法、使用口腔内装置或心理治疗）中哪一种最适合磨牙症不同表现的临床管理，尚无定论。本系统评价和网状Meta分析的目的是回答以下问题：对于成年磨牙症患者，最佳治疗方法是什么？
方法/设计：将使用以下关键词对Cochrane图书馆、MEDLINE（通过PubMed）、Scopus和LILACS进行全面检索：磨牙症、治疗方法及相关检索词。将根据纳入标准（对照临床试验和随机临床试验，并考虑磨牙症的特定结局指标）纳入研究。将手工检索纳入研究的参考文献列表。将使用专门设计的数据提取表从纳入研究中提取相关数据。将评估纳入研究的偏倚风险，并总结证据的总体强度（即GRADE）。所有成对Meta分析将使用随机效应模型（95%置信区间）。贝叶斯网状Meta分析将探讨各种治疗方法之间的相对益处。本评价将按照纳入网状Meta分析的系统评价的首选报告项目（PRISMA-NMA）声明进行报告。
讨论
本系统评价旨在识别和评估治疗磨牙症的疗法。本系统评价可能会为患者和研究人员带来多项建议，即针对特定患者病例哪种疗法最佳，以及考虑到现有情况和患者实际情况，未来研究应如何设计。
系统评价注册
PROSPERO CRD42015023308
Zotero 插件