Rojas J I, Patrucco L, MIguez J, Sinay V, Cassara F Pagani, Cáceres F, Liguori N Fernandez, Saladino M L, Deri N, Jaacks G, Marcilla M Parada, Arrigoni M I, Correale J, Fiol M, Ysrraelit M C, Carrá A, Curbelo M C, Martinez A, Steinberg J, Bestoso S, Hryb J P, Di Pace J L, Perassolo M B, Contentti E Carnero, Caride A, Lopez P A, Martinez C, Reich E, Giunta D, Cristiano E
Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
J Clin Neurosci. 2017 Apr;38:84-86. doi: 10.1016/j.jocn.2016.12.030. Epub 2017 Jan 10.
Several studies in multiple sclerosis (MS) suggest a trend of increasing disease frequency in women during the last decades. A direct comparison of gender ratio trends among MS populations from Argentina remains to be carried out. The objective of the study was to compare gender ratio trends, over a 50-year span in MS populations from Argentina.
multicenter study that included patients from 14 MS Centers of Argentina. Patients with definite MS with birth years ranging from 1940 to 1989 were included. Gender ratios were calculated by five decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the Argentinean national registry of births. The F/M ratios were calculated using a multivariate logistic regression per five decades by the year of birth approach. Analyses were performed using Stata 10.1.
1069 patients were included. Gender ratios showed a significant increase from the first to the last decade in the whole MS sample (from 1.8 to 2.7; p value for trend=0.023). The Gender ratio did not show differences considering MS subtype.
our study showed a modest increase of the F/M ratio (from 1.8 to 2.7) over time among patients affected by MS in Argentina.
多项针对多发性硬化症（MS）的研究表明，在过去几十年中，女性患该疾病的频率呈上升趋势。阿根廷MS人群的性别比趋势仍有待进行直接比较。本研究的目的是比较阿根廷MS人群在50年期间的性别比趋势。
一项多中心研究，纳入了来自阿根廷14个MS中心的患者。纳入出生年份在1940年至1989年之间的确诊MS患者。根据出生年份，每十年计算一次性别比，并根据阿根廷国家出生登记处得出的男女活产比进行调整。采用按出生年份每十年进行一次多变量逻辑回归的方法计算男女比。使用Stata 10.1进行分析。
共纳入1069例患者。在整个MS样本中，性别比从第一个十年到最后一个十年显著增加（从1.8增至2.7；趋势p值=0.023）。考虑MS亚型时，性别比未显示出差异。
我们的研究表明，随着时间的推移，阿根廷MS患者的男女比略有增加（从1.8增至2.7）。
