Inserm, CIC-1433 Clinical Epidemiology, CHRU de Nancy, University of Lorraine, 9 Allée du Morvan, 54505, Vandoeuvre-les-Nancy, France.
Département of Neurology, CHRU de Nancy, 29 Avenue du Maréchal de Lattre de Tassigny, 54000, Nancy, France.
Sci Rep. 2022 Jan 19;12(1):1001. doi: 10.1038/s41598-022-04836-5.
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. An increase in MS incidence over time is reported in several regions of the world. We aimed to describe the evolution of the annual MS incidence in the Lorraine region, France, from 1996 to 2015 and to analyze potential components of a possible change by a temporal effect of age at MS onset, MS onset period, and birth cohort, overall and for each sex. Cases were identified from ReLSEP, a population-based registry of MS cases living in Lorraine, northeastern France, with MS onset between 1996 and 2015. Age-period-cohort modeling was used to describe trends in MS incidence. Annual age- and sex-standardized incidences were relatively stable: 6.76/100 000 population (95%CI [5.76-7.91]) in 1996 and 6.78/100 000 (95%CI [5.72-7.97]) in 2015. The incidence ratio between women and men was 2.4. For all time periods, the peak incidence occurred between ages 25 and 35 years. Age-period-adjusted cohort and age-cohort-adjusted period analyses did not reveal a period or cohort effect. The incidence of MS remained stable over the study period in Lorraine, and we could not identify any particular effect of disease onset period or birth period on this evolution.
多发性硬化症（MS）是一种中枢神经系统的神经退行性疾病。据报道，世界上多个地区的 MS 发病率呈上升趋势。我们旨在描述法国洛林地区 1996 年至 2015 年期间 MS 发病率的演变，并通过 MS 发病年龄、发病期和出生队列的时间效应分析可能变化的潜在因素，总体上和按性别分别进行分析。病例是从 ReLSEP 中确定的，这是一个基于人群的 MS 病例登记处，位于法国东北部的洛林地区，1996 年至 2015 年期间发病。使用年龄-时期-队列模型来描述 MS 发病率的趋势。每年年龄和性别标准化的发病率相对稳定：1996 年为 6.76/100000 人口（95%CI [5.76-7.91]），2015 年为 6.78/100000（95%CI [5.72-7.97]）。女性和男性的发病率比值为 2.4。在所有时期，发病高峰期都在 25 至 35 岁之间。年龄-时期调整的队列和年龄-队列调整的时期分析均未显示出时期或队列效应。洛林地区的 MS 发病率在研究期间保持稳定，我们无法确定发病期或出生期对这种演变有任何特殊影响。
