空腹血糖升高和蛋白尿可能是北昆士兰土著成年人全因死亡率的一个标志物——一项1998 - 2006年的随访研究。

Elevated fasting glucose and albuminuria may be a marker for all-cause mortality in Indigenous adults in North Queensland - a follow up study, 1998-2006.

作者信息

Li Ming, McDermott Robyn

机构信息

Centre of Population Health Research, University of South Australia, IPC CWE-48, GPO Box 2471, Adelaide, SA, Australia 5001.

Centre of Population Health Research, University of South Australia, IPC CWE-48, GPO Box 2471, Adelaide, SA, Australia 5001; Faculty of Medicine, Health & Molecular Sciences, James Cook University, Cairns, Australia 4870;.

出版信息

J Diabetes Complications. 2017 Apr;31(4):708-714. doi: 10.1016/j.jdiacomp.2016.12.008. Epub 2017 Jan 5.

DOI:10.1016/j.jdiacomp.2016.12.008

PMID:28087205

Abstract

AIMS

To document risk factors of all-cause mortality in a cohort of indigenous Australians from 23 communities of North Queensland during 1998-2006.

METHODS

Among 2787 indigenous adults, baseline weight, waist circumference, blood pressure, fasting glucose, lipids, gamma-glutamyl transferase, urine albumin creatinine ratio, smoking, alcohol intake and physical activity were measured in 1998-2000. Deaths were ascertained from State Registry of Deaths, hospitalization and clinical records till 2006. Mortality risk factors were assessed using a Cox proportional-hazards model.

RESULTS

The standardized all-cause mortality rate was 23.2/1000 person-years (95% CI 20.3-26.3/1000 pys). After adjusting for age, sex, and ethnicity, baseline plasm fasting glucose >=5.5mmol/L was associated with a 50% increased risk of death (HR 1.5, 95% CI 1.2-2.0). Albuminuria was associated with all-cause mortality with a hazards ratio of 1.4 for microalbuminuria (95% CI 1.0-1.9) and 2.6 (95% CI 1.8-3.7) for macroalbuminuria. Gamma-glutamyl transferase >=50IU was associated with an increased risk of all-cause mortality by 40% (95% CI 1.04-1.8).

CONCLUSIONS

Fasting glycaemia, albuminuria, and gamma-glutamyl transferase, may be a marker for all-cause mortality within this cohort.

摘要

目的

记录1998 - 2006年期间北昆士兰23个社区的澳大利亚原住民队列中全因死亡率的风险因素。

方法

在2787名原住民成年人中，于1998 - 2000年测量了基线体重、腰围、血压、空腹血糖、血脂、γ-谷氨酰转移酶、尿白蛋白肌酐比值、吸烟、酒精摄入量和身体活动情况。通过州死亡登记处、住院记录和临床记录确定直至2006年的死亡情况。使用Cox比例风险模型评估死亡率风险因素。

结果

标准化全因死亡率为23.2/1000人年（95%可信区间20.3 - 26.3/1000人年）。在调整年龄、性别和种族后，基线血浆空腹血糖≥5.5mmol/L与死亡风险增加50%相关（风险比1.5，95%可信区间1.2 - 2.0）。蛋白尿与全因死亡率相关，微量蛋白尿的风险比为1.4（95%可信区间1.0 - 1.9），大量蛋白尿的风险比为2.6（95%可信区间1.8 - 3.7）。γ-谷氨酰转移酶≥50IU与全因死亡率风险增加40%相关（95%可信区间1.04 - 1.8）。