Zhang Wenming, Holyoke Caleb W, Barry James, Cordova Daniel, Leighty Robert M, Tong My-Hanh T, Hughes Kenneth A, Lahm George P, Pahutski Thomas F, Xu Ming, Briddell Twyla A, McCann Stephen F, Henry Yewande T, Chen Yuzhong
DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA.
Bioorg Med Chem Lett. 2017 Feb 15;27(4):911-917. doi: 10.1016/j.bmcl.2017.01.002. Epub 2017 Jan 5.
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species. In this communication, we report the part of the optimization program that led to the identification of dicloromezotiaz as a potent insecticide to control a broad range of lepidoptera. Our efforts in discovery, synthesis, structure-activity relationship elucidation, and biological activity evaluation are also presented.
已发现一类新型的中氮茚并[1,2 - a]嘧啶酮，具有卓越的杀虫活性，可控制多种昆虫物种。在本通讯中，我们报告了优化计划的一部分，该计划导致鉴定出二氯美唑噻作为一种有效的杀虫剂，可控制多种鳞翅目昆虫。我们还介绍了在发现、合成、构效关系阐明和生物活性评估方面所做的工作。
