Holyoke Caleb W, Cordova Daniel, Zhang Wenming, Barry James D, Leighty Robert M, Dietrich Robert F, Rauh James J, Pahutski Thomas F, Lahm George P, Tong My-Hanh Thi, Benner Eric A, Andreassi John L, Smith Rejane M, Vincent Daniel R, Christianson Laurie A, Teixeira Luis A, Singh Vineet, Hughes Kenneth A
DuPont Crop Protection, Stine-Haskell Research Center, Newark, DE, USA.
E.I. DuPont India Pvt Ltd, South Asia Field Experimental Station, Vadodara, Gujarat, India.
Pest Manag Sci. 2017 Apr;73(4):796-806. doi: 10.1002/ps.4496. Epub 2017 Feb 1.
As the world population grows towards 9 billion by 2050, it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20-49% loss of global crop yields owing to pests. The development of new insecticides will help to sustain this protection and overcome insecticide resistance.
A novel class of mesoionic compounds has been discovered, with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera. These compounds bind to the orthosteric site of the nicotinic acetylcholine receptor and result in a highly potent inhibitory action at the receptor with minimal agonism. The synthesis, biological activity, optimization and mode of action will be discussed.
Triflumezopyrim insect control will provide a powerful tool for control of hopper species in rice throughout Asia. Dicloromezotiaz can provide a useful control tool for lepidopteran pests, with an underexploited mode of action among these pests. © 2016 Society of Chemical Industry.
随着世界人口预计到2050年增长至90亿，预计粮食产量将需要增加60%。这种增长的一个关键部分包括安全有效地使用杀虫剂，以减少估计因害虫造成的全球作物产量20% - 49%的损失。新型杀虫剂的开发将有助于维持这种保护并克服抗药性。
已发现一类新型的中离子化合物，对一系列半翅目和鳞翅目昆虫具有卓越的杀虫活性。这些化合物与烟碱型乙酰胆碱受体的正构位点结合，并在该受体上产生高效抑制作用，激动作用极小。将讨论其合成、生物活性、优化及作用方式。
三氟甲吡嘧对亚洲各地稻田中稻飞虱种类的防治将提供一个强有力的工具。二氯美唑噻可作为防治鳞翅目害虫的有效工具，在这些害虫中其作用方式尚未得到充分利用。© 2016化学工业协会。
