Morrison Caroline F, Martsolf Donna M, Wehrkamp Nicole, Tehan Rebecca, Pai Ahna L H
Center for the Promotion of Adherence and Self-Management, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
College of Nursing, University of Cincinnati, Cincinnati, Ohio.
Biol Blood Marrow Transplant. 2017 Apr;23(4):562-568. doi: 10.1016/j.bbmt.2017.01.008. Epub 2017 Jan 10.
Adherence to oral medications has been repeatedly shown to fall below the recommended 80% to 95% in pediatric and adult cancer populations. The purpose of this review is to report the state of the science about oral medication adherence during the acute phase of hematopoietic stem cell transplantation across the lifespan. An exhaustive search of the literature yielded 5 records for inclusion in the review. Two studies examined adherence in pediatrics, 2 in adults, and 1 included both pediatric and adult patients. Three studies were descriptive and 2 were interventional in design. The rate of adherence to oral medications ranged from 33% to 94.7%. Adherence decreased over time in all studies except in 1 pharmacist-led intervention study. Different methods were used to measure adherence, but most relied on self-report. Further research is needed in medication adherence in hematopoietic stem cell transplantation to better understand facilitators, barriers, and relationships to health outcomes.
在儿科和成人癌症患者群体中，口服药物的依从性一再被证明低于推荐的80%至95%。本综述的目的是报告在造血干细胞移植急性期，全生命周期口服药物依从性的科学现状。对文献进行详尽检索后，有5篇记录被纳入本综述。两项研究考察了儿科患者的依从性，两项针对成人，一项纳入了儿科和成人患者。三项研究为描述性研究，两项为干预性研究。口服药物的依从率在33%至94.7%之间。除了一项由药剂师主导的干预性研究外，在所有研究中依从性都随时间下降。采用了不同的方法来测量依从性，但大多数依赖自我报告。造血干细胞移植中的药物依从性还需要进一步研究，以更好地了解促进因素、障碍以及与健康结果的关系。
