Seleit Ali, Krämer Isabel, Ambrosio Elizabeth, Dross Nicolas, Engel Ulrike, Centanin Lázaro
Animal Physiology and Development, Centre for Organismal Studies (COS) Heidelberg, Im Neuenheimer Feld 230, Heidelberg 69120, Germany.
The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.
Development. 2017 Feb 15;144(4):687-697. doi: 10.1242/dev.142752. Epub 2017 Jan 13.
Animal organs are typically formed during embryogenesis by following one specific developmental programme. Here, we report that neuromast organs are generated by two distinct and sequential programmes that result in parallel sensory lines in medaka embryos. A ventral posterior lateral line (pLL) is composed of neuromasts deposited by collectively migrating cells whereas a midline pLL is formed by individually migrating cells. Despite the variable number of neuromasts among embryos, the sequential programmes that we describe here fix an invariable ratio between ventral and midline neuromasts. Mechanistically, we show that the formation of both types of neuromasts depends on the chemokine receptor genes and , illustrating how common molecules can mediate different morphogenetic processes. Altogether, we reveal a self-organising feature of the lateral line system that ensures a proper distribution of sensory organs along the body axis.
动物器官通常在胚胎发育过程中通过遵循一个特定的发育程序形成。在此，我们报告神经丘器官是由两个不同且连续的程序产生的，这两个程序在青鳉胚胎中形成平行的感觉线。腹侧后外侧线（pLL）由集体迁移的细胞沉积的神经丘组成，而中线pLL由单个迁移的细胞形成。尽管胚胎之间神经丘的数量各不相同，但我们在此描述的连续程序确定了腹侧和中线神经丘之间不变的比例。从机制上讲，我们表明这两种类型的神经丘的形成都依赖于趋化因子受体基因 和 ，说明了常见分子如何介导不同的形态发生过程。总之，我们揭示了侧线系统的一种自组织特征，该特征确保感觉器官沿身体轴的适当分布。
