恶性血管内皮瘤病：一种亲血管性淋巴瘤。

Malignant angioendotheliomatosis: an angiotropic lymphoma.

作者信息

Petroff N, Koger O W, Fleming M G, Fishleder A, Bergfeld W F, Tuthill R, Tubbs R

机构信息

Cleveland Clinic Foundation, OH 44106.

出版信息

J Am Acad Dermatol. 1989 Oct;21(4 Pt 1):727-33. doi: 10.1016/s0190-9622(89)70245-0.

DOI:10.1016/s0190-9622(89)70245-0

PMID:2808788

Abstract

Malignant angioendotheliomatosis is a rare, systemic, usually fatal disease characterized by massive proliferation of large, neoplastic, mononuclear cells within the lumen of small blood vessels. Recent studies suggested that the tumor cells are of lymphoid origin. We studied two cases of malignant angioendotheliomatosis by Southern blot hybridization analysis that showed rearrangements of the immunoglobulin heavy chain and kappa light chain (case 2), indicating the presence of a monoclonal B cell lymphoma. Our results provide further evidence that malignant angioendotheliomatosis is an angiotropic lymphoma.

摘要

恶性血管内皮瘤病是一种罕见的全身性疾病，通常致命，其特征是小血管腔内大量出现大型、肿瘤性单核细胞增殖。最近的研究表明，肿瘤细胞起源于淋巴细胞。我们通过Southern印迹杂交分析研究了两例恶性血管内皮瘤病，结果显示免疫球蛋白重链和κ轻链发生重排（病例2），提示存在单克隆B细胞淋巴瘤。我们的结果进一步证明恶性血管内皮瘤病是一种亲血管性淋巴瘤。