Alexiadis A, Stamatopoulos K, Wen W, Batchelor H K, Bakalis S, Barigou M, Simmons M J H
School of Chemical Engineering, University of Birmingham, Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
School of Chemical Engineering, University of Birmingham, Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Comput Biol Med. 2017 Feb 1;81:188-198. doi: 10.1016/j.compbiomed.2017.01.003. Epub 2017 Jan 9.
We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data.
我们开发了一个数学模型，该模型描述了由柔性壁的周期性收缩（蠕动）引起的部分充满液体的结肠中粘性流体的运动。体外数据用于验证该模型。然后，该模型被用于识别质量传输的两种基本机制：冲浪模式和倾泻模式。第一种机制速度更快，但仅涉及液体表面。第二种机制会导致更深层次的混合，并且似乎是主要的传输机制。基于所获得的认识，我们提出了一系列可以提高体外模型可靠性的措施。特别是在类似PET的实验中，示踪剂不应注入第一个腔室，并且其粘度应尽可能接近流体的粘度。如果不满足这些条件，示踪剂和流体的动力学就会出现偏差，从而影响体外数据的准确性。
