Cao J, Yuan B, Guo P X, Zhu H Q, Huang Z Z, He Y, Ding Q, Feng Z Z
Department of Psychology, Military Preventive Medicine Institution, Third Military Medical University, Chongqing 648800, China.
Zhonghua Xue Ye Xue Za Zhi. 2016 Dec 14;37(12):1033-1037. doi: 10.3760/cma.j.issn.0253-2727.2016.12.004.
To investigate the influence of depression levels on regulatory T cells (Tregs) in patients with non-M acute myeloid leukemia (AML). A total of 63 patients with primarily diagnostic non-M AML and 25 healthy controls were enrolled, and the levels of depression by using HADM score and the percentages of Tregs by flow cytometry were evaluated in pre-treatment and post-treatment, respectively. After every course of chemotherapy, the percentages of Tregs of PBMNC in AML showed the higher level of (6.48±1.81)% than those of (4.99±1.29)% in control (= 0.001). There was no difference among different levels of depression groups after the first cycle. However, the percentages of Tregs increased with the worse of depression after the second and third cycles. Partial correlation analysis after adjusting age indicated that the percentages of Tregs showed no correlation with the levels of depression after the first cycle (correlation coefficient, 0.120, =0.345), and showed the positive correlation with depression levels after the second and third cycles (correlation coefficient, 0.619 and 0.614, all values <0.05). The depression levels showed an association with the percentages of Tregs in patients with non-M AML, which could be observed only after the second cycles of chemotherapy.
探讨非M型急性髓系白血病（AML）患者抑郁水平对调节性T细胞（Tregs）的影响。共纳入63例初诊非M型AML患者和25例健康对照，分别在治疗前和治疗后采用医院焦虑抑郁量表（HADM）评分评估抑郁水平，采用流式细胞术检测Tregs百分比。每疗程化疗后，AML患者外周血单个核细胞（PBMNC）中Tregs百分比为（6.48±1.81）%，高于对照组的（4.99±1.29）%（P = 0.001）。第1周期后不同抑郁水平组间无差异。然而，第2周期和第3周期后，Tregs百分比随抑郁程度加重而升高。校正年龄后的偏相关分析显示，第1周期后Tregs百分比与抑郁水平无相关性（相关系数，0.120，P = 0.345），第2周期和第3周期后与抑郁水平呈正相关（相关系数，0.619和0.614，均P值<0.05）。抑郁水平与非M型AML患者Tregs百分比相关，且仅在化疗第2周期后可观察到。
