Ehgoetz Martens Kaylena A, Lewis Simon J G
Parkinson Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, 2050, NSW, Australia.
Parkinson Disease Research Clinic, Brain and Mind Centre, University of Sydney, 100 Mallet Street, Camperdown, 2050, NSW, Australia.
J Neurol Sci. 2017 Mar 15;374:9-16. doi: 10.1016/j.jns.2016.12.062. Epub 2016 Dec 29.
Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impaired neural circuits and dysfunctional global networks. The objective of this chapter is to provide an overview of the array of pathological changes that have been linked to different behavioral symptoms of PD such as depression, anxiety, apathy, fatigue, impulse control disorders, psychosis, sleep disorders and dementia.
帕金森病（PD）中的异常行为源于神经网络受损的复杂协调，这种受损是由多个层面上与PD相关的神经退行性变导致的。通常，细胞和组织异常会产生神经化学变化并破坏大脑的特定区域，进而导致神经回路受损和整体网络功能失调。本章的目的是概述一系列与PD不同行为症状相关的病理变化，这些症状包括抑郁、焦虑、冷漠、疲劳、冲动控制障碍、精神病、睡眠障碍和痴呆。
