血清乳脂肪球表皮生长因子8（MFG-E8）浓度降低与2型糖尿病患者微血管并发症风险增加相关。

Reduced serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes.

作者信息

Sun Guohua, Liu Juxiang, Xia Guanghao, Zhang Lijuan, Li Yonghong, Zhou Zubang, Lv Yaya, Wei Suhong, Liu Jing, Quan Jinxing

机构信息

Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Ningxia Medical University, Yinchuan, China.

Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China; Key Lab of Endocrine and Metabolic Diseases of Gansu Province, Lanzhou, China.

出版信息

Clin Chim Acta. 2017 Mar;466:201-206. doi: 10.1016/j.cca.2017.01.013. Epub 2017 Jan 12.

DOI:10.1016/j.cca.2017.01.013

PMID:28089751

Abstract

BACKGROUND

The association between serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations and vascular complications in T2DM remains unclear.

METHODS

A total of 149 patients with T2DM were included. The serum concentrations of MFG-E8, glycosylated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured.

RESULTS

There was no significant difference in serum MFG-E8 concentrations between the T2DM group and the T2DM with subclinical atherosclerosis (AS) group (615.49±143.54 vs. 596.22±79.46ng/ml, P=0.365), while the serum concentrations of MFG-E8 in the T2DM with microvascular complications group (446.70±61.53ng/ml) and the T2DM with subclinical AS and microvascular complications group (200.87±38.86ng/ml) were significantly lower than those in the T2DM group (P=0.000 for both). In addition, hs-CRP and HbAlc concentrations were independently associated with serum MFG-E8 concentrations (P=0.024 and P=0.01, respectively), and low serum MFG-E8 concentrations were significantly associated with an increased risk of microvascular complications in T2DM patients.

CONCLUSIONS

Serum concentrations of MFG-E8 were negatively associated with the risk of microvascular complications in patients with T2DM. Thus, it might be a potential candidate biomarker for diabetic microvascular complications.

摘要

背景

2型糖尿病（T2DM）患者血清乳脂肪球表皮生长因子8（MFG-E8）浓度与血管并发症之间的关联尚不清楚。

方法

共纳入149例T2DM患者。检测血清MFG-E8、糖化血红蛋白（HbA1c）和高敏C反应蛋白（hs-CRP）浓度。

结果

T2DM组与合并亚临床动脉粥样硬化（AS）的T2DM组血清MFG-E8浓度无显著差异（615.49±143.54 vs. 596.22±79.46ng/ml，P=0.365），而合并微血管并发症的T2DM组（446.70±61.53ng/ml）和合并亚临床AS及微血管并发症的T2DM组（200.87±38.86ng/ml）血清MFG-E8浓度显著低于T2DM组（两者P均=0.000）。此外，hs-CRP和HbAlc浓度与血清MFG-E8浓度独立相关（分别为P=0.024和P=0.01），低血清MFG-E8浓度与T2DM患者微血管并发症风险增加显著相关。