Ingram David G, Churchill Shervin S
Division of Pulmonary and Sleep Medicine, Children's Mercy Hospital, Kansas City, Missouri.
Department of Family and Child Nursing, University of Washington, Seattle, Washington.
Pediatr Neurol. 2017 Feb;67:85-90. doi: 10.1016/j.pediatrneurol.2016.10.002. Epub 2016 Oct 8.
Very little is known about sleep habits in children with agenesis of the corpus callosum (ACC). The purpose of this investigation was to evaluate sleep problems in children with ACC and examine the association with quality of life.
We performed a cross-sectional, anonymous, internet-based survey offered to parents of children with ACC, aged five to 18 years. The Children's Sleep Habits Questionnaire (CSHQ) and pediatric quality of life (PedsQL) were used to assess sleep habits and quality of life, respectively. Associations between the total and all subdomains of CSHQ and PedsQL were tested.
The final sample included 66 parents of children with ACC. Overall, 78% of the children had clinically significant sleep problems, using a cutoff score of 41 on the CSHQ. Compared with a prior national sample of typically developing children, children with ACC scored significantly higher overall and in all subdomains of the CSHQ. The overall CSHQ and PedsQL were moderately correlated (r = -0.485, P < 0.001), indicating that children with more sleep problems had worse quality of life. In addition, the total CSHQ correlated with all subdomains of the pediatric quality of life, including emotional (r = -0.515, P < 0.01), social (r = -0.394, P < 0.01), physical (r = -0.263, P < 0.01), and school (r = -0.362, P < 0.01). These associations remained statistically significant in multivariable regression models controlling for age and gender.
Sleep problems are common and associated with lower quality of life in children with ACC.
关于胼胝体发育不全（ACC）患儿的睡眠习惯，人们知之甚少。本研究旨在评估ACC患儿的睡眠问题，并探讨其与生活质量的关联。
我们开展了一项横断面、匿名的基于互联网的调查，面向5至18岁ACC患儿的家长。分别使用儿童睡眠习惯问卷（CSHQ）和儿童生活质量量表（PedsQL）评估睡眠习惯和生活质量。对CSHQ总分及所有子领域与PedsQL之间的关联进行了测试。
最终样本包括66名ACC患儿的家长。总体而言，以CSHQ得分为41作为临界值，78%的患儿存在具有临床意义的睡眠问题。与之前全国范围内发育正常儿童的样本相比，ACC患儿在CSHQ总分及所有子领域的得分均显著更高。CSHQ总分与PedsQL呈中度相关（r = -0.485，P < 0.001），表明睡眠问题较多的患儿生活质量较差。此外，CSHQ总分与儿童生活质量的所有子领域均相关，包括情绪（r = -0.515，P < 0.01）、社交（r = -0.394，P < 0.01）、身体（r = -0.263，P < 0.01）和学校（r = -0.362，P < 0.01）。在控制年龄和性别的多变量回归模型中，这些关联仍具有统计学意义。
睡眠问题在ACC患儿中很常见，且与较低的生活质量相关。
