Université Lyon 1, Université de Lyon, Lyon, France; Institut Universitaire de Technologie Lyon1, Université de Lyon, F-69622 Villeurbanne Cedex, France; INSERM U1052, Cancer Research Center of Lyon, F-69373 Lyon Cedex 08, France; CNRS UMR 5286, Cancer Research Center of Lyon, F-69373 Lyon Cedex 08, France; ProfileXpert, SFR-Est, CNRS UMR-S3453, INSERM US7, F-69373 Lyon Cedex 08, France.
ViroScan3D, F-01600 Trévoux, France.
Mol Cell Endocrinol. 2017 Nov 15;456:51-61. doi: 10.1016/j.mce.2017.01.021. Epub 2017 Jan 13.
Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids.
自从首次在正常垂体中观察到 microRNAs 的存在以来，大多数涉及它们在垂体中的作用和功能的科学出版物都是基于垂体肿瘤的研究。在这篇综述中，我们简要描述了 microRNAs 参与垂体激素合成的情况，并全面列出了 microRNA 对垂体肿瘤的抑制因子和诱导因子。最后，我们总结了 microRNAs 在垂体肿瘤发生、发展和侵袭中的功能作用，以及导致这些肿瘤中 microRNAs 调控（转录因子、基因组修饰或表观遗传）或调节（药物治疗）的机制，以及深入研究体液中 miRNAs 表达的意义。
