Department of Endocrinology and Nephrology, University Hospital, Leipzig, Germany.
Department of Endocrinology and Nephrology, University Hospital, Leipzig, Germany.
Mol Cell Endocrinol. 2017 Dec 15;458:156-159. doi: 10.1016/j.mce.2017.01.011. Epub 2017 Jan 12.
Thyroid hormone (TH) disorders are associated with profound changes in whole body energy metabolism. A major TH target is thermogenic brown adipose tissue (BAT), which can be stimulated directly through thyroid hormone receptors (TRs) expressed in brown adipocytes and indirectly, through TRs expressed in hypothalamic neurons. White adipose tissue (WAT) adopts BAT characteristics by a diverse range of stimuli in a process referred to as browning. It is now understood that TH also induce WAT browning through peripheral and central mechanisms. In this review, we discuss evidence from animal and human studies that TH disorders are associated with changes in both BAT thermogenesis and WAT browning, thereby influencing body temperature and body weight regulation.
甲状腺激素（TH）紊乱与全身能量代谢的深刻变化有关。甲状腺激素受体（TR）在棕色脂肪细胞中的表达使棕色脂肪组织（BAT）成为主要的 TH 靶标，这可以直接刺激，而在下丘脑神经元中的表达则可以间接刺激。通过各种刺激，白色脂肪组织（WAT）会呈现出 BAT 的特征，这个过程被称为“褐变”。现在人们已经知道，TH 通过外周和中枢机制也能诱导 WAT 褐变。在这篇综述中，我们讨论了来自动物和人类研究的证据，表明 TH 紊乱与 BAT 产热和 WAT 褐变的变化有关，从而影响体温和体重调节。
