Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Department of Cardiology, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, PR China.
Biogerontology. 2024 Nov;25(6):1011-1024. doi: 10.1007/s10522-024-10137-3. Epub 2024 Oct 8.
Brown Adipose Tissue (BAT) is a type of fat tissue that can generate heat and plays an important role in regulating body temperature and energy metabolism. Enhancing BAT activity through medication, exercise and other means has become a potential effective method for treating metabolic disorders. Recently, there has been increasing evidence suggesting a link between BAT and aging. As humans age, the volume and activity of BAT decrease, which may contribute to the development of age-related diseases. Multiple organelles signaling pathways have been reported to be involved in the aging process associated with BAT. Therefore, we aimed to review the evidence related to the association between aging process and BAT decreasing, analyze the potential of BAT as a predictive marker for age-related diseases, and explore potential therapeutic strategies targeting BAT for aging interventions and healthy longevity.
棕色脂肪组织（BAT）是一种能够产热的脂肪组织，在调节体温和能量代谢方面发挥着重要作用。通过药物、运动等手段增强 BAT 活性已成为治疗代谢紊乱的一种潜在有效方法。最近，越来越多的证据表明 BAT 与衰老之间存在关联。随着人类年龄的增长，BAT 的体积和活性会减少，这可能导致与年龄相关的疾病的发生。据报道，多种细胞器信号通路参与与 BAT 相关的衰老过程。因此，我们旨在综述与衰老过程和 BAT 减少相关的证据，分析 BAT 作为与年龄相关的疾病预测标志物的潜力，并探索针对 BAT 的潜在治疗策略，以实现衰老干预和健康长寿。
