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肾脏病与肥胖:流行病学、发病机制与治疗。

Kidney disease and obesity: epidemiology, mechanisms and treatment.

机构信息

Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Avenue Professor Lineu Prestes 1730, ICB IV, 05508-000, São Paulo, Brazil.

Clinical Research Support Center, Tomishiro Central Hospital, Ueda 25, Tomigusuku City 901-0243, Okinawa, Japan.

出版信息

Nat Rev Nephrol. 2017 Mar;13(3):181-190. doi: 10.1038/nrneph.2016.191. Epub 2017 Jan 16.

DOI:10.1038/nrneph.2016.191
PMID:28090083
Abstract

The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed.

摘要

2017 年世界肾脏日的主题是“肾脏疾病与肥胖:健康肾脏,健康生活”。为了纪念这一事件,《自然综述:肾病学》杂志邀请了五位顶尖研究人员来描述肥胖相关肾脏疾病的流行病学变化,以及目前对其发病机制和治疗方法的最新认识。研究人员还强调了可能导致新疗法开发的新进展,并确定了需要进一步开展基础和临床研究的领域。

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本文引用的文献

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Renal, metabolic and cardiovascular considerations of SGLT2 inhibition.SGLT2 抑制的肾脏、代谢和心血管考虑因素。
Nat Rev Nephrol. 2017 Jan;13(1):11-26. doi: 10.1038/nrneph.2016.170. Epub 2016 Dec 12.
2
Estimated GFR Before and After Bariatric Surgery in CKD.慢性肾脏病患者减重手术后的估计肾小球滤过率前后对比
Am J Kidney Dis. 2017 Mar;69(3):380-388. doi: 10.1053/j.ajkd.2016.09.020. Epub 2016 Dec 4.
3
Kidney outcomes three years after bariatric surgery in severely obese adolescents.重度肥胖青少年接受减肥手术后三年的肾脏转归
1990-2021年慢性肾脏病全球负担及其归因风险因素:基于全球疾病负担研究的分析
Front Endocrinol (Lausanne). 2025 Jul 3;16:1563246. doi: 10.3389/fendo.2025.1563246. eCollection 2025.
4
Analyzing the association of estimated pulse wave velocity with the risk and mortality of chronic kidney disease: a study based on the NHANES database.分析估计脉搏波速度与慢性肾脏病风险及死亡率的关联:一项基于美国国家健康与营养检查调查(NHANES)数据库的研究
Int Urol Nephrol. 2025 Jul 14. doi: 10.1007/s11255-025-04660-6.
5
Association between obesity indexes and chronic kidney disease risk: a double-cohort prospective study in the Binhai and UK Biobank.肥胖指数与慢性肾脏病风险之间的关联:一项在滨海地区和英国生物银行进行的双队列前瞻性研究
Front Endocrinol (Lausanne). 2025 Jun 27;16:1566011. doi: 10.3389/fendo.2025.1566011. eCollection 2025.
6
Decoding mA RNA methylation in kidney disorders: from molecular insights to therapeutic strategies.解析肾脏疾病中的mRNA甲基化:从分子洞察到治疗策略
J Transl Med. 2025 Jul 10;23(1):771. doi: 10.1186/s12967-025-06817-4.
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Biol Trace Elem Res. 2025 Jun 5. doi: 10.1007/s12011-025-04663-5.
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Kidney Int. 2017 Feb;91(2):451-458. doi: 10.1016/j.kint.2016.09.031. Epub 2016 Dec 1.
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