Swoboda Peter P, McDiarmid Adam K, Page Stephen P, Greenwood John P, Plein Sven
Multidisciplinary Cardiovascular Research Centre and Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Guy's and St Thomas' NHS Foundation Trust, London, UK.
Eur Cardiol. 2016 Winter;11(2):96-101. doi: 10.15420/ecr/2016:28:2.
T1 mapping by cardiovascular magnetic resonance is a rapidly evolving method for the quantitative assessment of tissue characteristics in cardiac disease. The myocardial T1 time can be measured without contrast (native T1) or following the administration of intravenous gadolinium-based contrast agent (post-contrast T1). By combining both of these measures, the myocardial extracellular volume fraction can be approximated. This value has been validated histologically in various inherited cardiomyopathies. Due to overlapping phenotypes, the diagnosis of inherited cardiomyopathy can at times be challenging. In this article we discuss when T1 mapping may be a useful tool in the differential diagnosis of cardiomyopathy. We also present evidence of when T1 mapping provides incremental risk stratification over other biomarkers.
心血管磁共振成像的T1映射是一种快速发展的方法，用于定量评估心脏病中的组织特征。心肌T1时间可以在不使用造影剂的情况下测量（固有T1），也可以在静脉注射钆基造影剂后测量（造影剂后T1）。通过结合这两种测量方法，可以近似估算心肌细胞外容积分数。该值已在各种遗传性心肌病中通过组织学方法得到验证。由于表型重叠，遗传性心肌病的诊断有时可能具有挑战性。在本文中，我们讨论了T1映射何时可能成为心肌病鉴别诊断的有用工具。我们还提供了证据，证明T1映射何时能比其他生物标志物提供更多的风险分层信息。
