May Megan Brafford, Glode Ashley
Baptist Health Lexington, Lexington, Kentucky; University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
J Adv Pract Oncol. 2016 Mar;7(2):181-187. doi: 10.6004/jadpro.2016.7.2.4. Epub 2016 Mar 1.
Statin use leads to a reduction in the downstream products of the mevalonate pathway. Knowledge of this pathway has led scientists to investigate the role of statins in cancer prevention and treatment. Statins appear to possess a variety of pleiotropic effects, including inhibition of cell proliferation; enhanced apoptosis; and modulation of inflammation, endothelial function, and angiogenesis. In cancer specifically, experimental studies have found that statins may induce cancer cell apoptosis and inhibit tumor growth, angiogenesis, and metastasis. These mechanisms have steered researchers into evaluating the possible benefit of statins in the prevention and treatment of malignancies. This review will discuss the literature supporting the use of statins to prevent and treat cancer.
他汀类药物的使用会导致甲羟戊酸途径下游产物的减少。对该途径的了解促使科学家们研究他汀类药物在癌症预防和治疗中的作用。他汀类药物似乎具有多种多效性作用，包括抑制细胞增殖、增强细胞凋亡以及调节炎症、内皮功能和血管生成。具体在癌症方面，实验研究发现他汀类药物可能诱导癌细胞凋亡并抑制肿瘤生长、血管生成和转移。这些机制促使研究人员评估他汀类药物在预防和治疗恶性肿瘤方面的潜在益处。本综述将讨论支持使用他汀类药物预防和治疗癌症的文献。
