抗苗勒管激素作为枸橼酸氯米芬治疗多囊卵巢综合征的预测指标。
Anti-Müllerian hormone as a predictor of polycystic ovary syndrome treated with clomiphene citrate.
作者信息
Hestiantoro Andon, Negoro Yuwono Sri, Afrita Yohana, Wiweko Budi, Sumapradja Kanadi, Natadisastra Muharam
机构信息
Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
出版信息
Clin Exp Reprod Med. 2016 Dec;43(4):207-214. doi: 10.5653/cerm.2016.43.4.207. Epub 2016 Dec 26.
OBJECTIVE
This study aimed to determine the threshold of anti-Müllerian hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC).
METHODS
Fifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed.
RESULTS
The AMH levels of patients with successful follicular growth were significantly lower (=0.001) than those with unsuccessful follicular growth (6.10±3.52 vs. 10.43±4.78 ng/mL). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (=0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y=-2.35+(-0.312×AMH level)+(0.464×fiber intake) (area under the curve, 0.88; 95% confidence interval, 0.79-0.98; <0.001).
CONCLUSION
The optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.
目的
本研究旨在确定抗苗勒管激素（AMH）作为预测接受枸橼酸氯米芬（CC）治疗的多囊卵巢综合征（PCOS）患者卵泡生长失败的阈值。
方法
招募了50名PCOS女性受试者，并根据卵泡生长成功与否分为两组。获取、评估并统计分析了相关变量，如年龄、不孕持续时间、吸烟情况、是否佩戴穆斯林头巾、阳光暴露情况、纤维摄入量、体重指数、腰围、AMH水平、25-羟基维生素D水平以及优势卵泡的生长情况。
结果
卵泡生长成功的患者的AMH水平显著低于卵泡生长失败的患者（P=0.001）（6.10±3.52 vs. 10.43±4.78 ng/mL）。与卵泡生长失败组相比，卵泡生长成功组的纤维摄入量也更高（P=0.001）。我们的研究发现卵泡生长成功的概率是AMH水平和纤维摄入量的函数，表达式为Y=-2.35+（-0.312×AMH水平）+（0.464×纤维摄入量）（曲线下面积，0.88；95%置信区间，0.79-0.98；P<0.001）。
结论
在预测接受CC治疗的PCOS患者卵泡生长失败方面，AMH水平的最佳阈值为8.58 ng/mL。
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