Maison Christèle, Quivy Jean-Pierre, Almouzni Geneviève
Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, Paris, France; Sorbonne Universités, UPMC Université Paris 06, CNRS, UMR3664, Paris, France.
Mol Cell Oncol. 2016 Aug 26;3(6):e1225546. doi: 10.1080/23723556.2016.1225546. eCollection 2016.
The Suv39h lysine methyltransferases, known as key enzymes responsible for histone H3 lysine 9 methylation, are critical for heterochromatin protein 1 enrichment at constitutive heterochromatin. Our recent findings reveal a new role for the Suv39h1 paralog that links it to SUMO pathway function at constitutive heterochromatin.
Suv39h赖氨酸甲基转移酶是负责组蛋白H3赖氨酸9甲基化的关键酶，对于组成型异染色质上异染色质蛋白1的富集至关重要。我们最近的研究结果揭示了Suv39h1旁系同源物的一个新作用，该作用将其与组成型异染色质上的SUMO途径功能联系起来。
