多发性硬化亚组中存在相似的家族风险。
Similar familial risk in multiple sclerosis subgroups.
机构信息
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
出版信息
Mult Scler. 2017 Nov;23(13):1782-1785. doi: 10.1177/1352458516684214. Epub 2017 Jan 16.
BACKGROUND
A subgroup of patients diagnosed with multiple sclerosis (MS) present with no oligoclonal bands (OCB) in the cerebrospinal fluid (CSF). Several studies report different clinical characteristics and genetic associations between the two groups.
OBJECTIVE
To investigate whether the OCB negative subgroup has a distinct etiology from band positive MS.
METHODS
Using nationwide registers to estimate familial risks, which reflect the genetic contribution of a disease.
RESULTS
Odds ratios of MS were similar for relatives to band positive and negative patients.
CONCLUSION
From the perspective of familial liability, MS without OCB is etiologically closely related to the dominant subgroup of OCB positive MS.
背景
诊断为多发性硬化症（MS）的患者亚组在脑脊液（CSF）中没有寡克隆带（OCB）。几项研究报告了这两个组之间不同的临床特征和遗传关联。
目的
研究 OCB 阴性亚组是否与带阳性 MS 具有不同的病因。
方法
利用全国性登记册来估计家族风险，这反映了疾病的遗传贡献。
结果
阳性和阴性患者的亲属的 MS 比值比相似。
结论
从家族易感性的角度来看，没有 OCB 的 MS 在病因上与 OCB 阳性 MS 的显性亚组密切相关。
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