Gromova O A, Pronin A V, Torshin I Yu, Kalacheva A G, Filimonova M V, Demidov V I, Gogoleva I V, Grishina T R
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia.
Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia, Moscow Institute of physics and technology, Dolgoprudny, Moscow region, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(11):69-77. doi: 10.17116/jnevro201611611169-77.
To investigate the effect of cerebrolysin on the growth and metastasis of malignant tumors in mice (a model of lung carcinoma Lewis).
The study was performed on 60 male mice, hybrids F1 (the age of 2-2.5 months, body weight 19-22g.). Transplantable epidermoid Lewis lung carcinoma (LLC) was used as a standard experimental model to evaluate the properties of the potential antitumor agents. Experimental animals were administered a single intraperitoneal injection of cerebrolysin in doses of 524 mg/kg (n=20) and 1800 mg/kg (n=20) daily from 2 to 16 days after tumor transplantation.
Compared with the control group (n=20), cerebrolysin induced growth inhibition of LLC during the treatment (7 to 16 days). An impact of the drug was accompanied by the inhibition of the tumor growth rate by 10-15% (p<0.05). Cerebrolysin demonstrated a dose-dependent effect of reducing the large number of metastases: a number of large metastases significantly decreased by 30-50% with the increase of cerebrolysin dose (p=0.01). Cerebrolysin can significantly suppress the growth rate of Lewis lung carcinoma.
研究脑蛋白水解物对小鼠（Lewis肺癌模型）恶性肿瘤生长和转移的影响。
对60只雄性F1杂种小鼠进行研究（年龄2 - 2.5个月，体重19 - 22克）。可移植的表皮样Lewis肺癌（LLC）用作标准实验模型来评估潜在抗肿瘤药物的特性。在肿瘤移植后第2天至第16天，对实验动物每天腹腔注射一次脑蛋白水解物，剂量分别为524毫克/千克（n = 20）和1800毫克/千克（n = 20）。
与对照组（n = 20）相比，脑蛋白水解物在治疗期间（第7天至第16天）可诱导LLC生长抑制。药物作用伴随着肿瘤生长速率抑制10 - 15%（p < 0.05）。脑蛋白水解物显示出减少大量转移灶的剂量依赖性效应：随着脑蛋白水解物剂量增加，大量转移灶数量显著减少30 - 50%（p = 0.01）。脑蛋白水解物可显著抑制Lewis肺癌的生长速率。
