Prylutska S V, Burlaka A P, Prylutskyy Yu I, Ritter U, Scharff P
Taras Shevchenko National University of Kyiv, Institute of Biology, Volodymyrska Str., 64, 01601 Kyiv, Ukraine.
Exp Oncol. 2011 Sep;33(3):162-4.
To estimate the impact of C(60) fullerene aqueous solution (C(60)FAS) on the rate of transplanted malignant tumor growth and metastasis.
Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used.
The C(60)FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%.
It was found that water-soluble pristine С(60) fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.
评估C60富勒烯水溶液（C60FAS）对移植性恶性肿瘤生长速率和转移的影响。
将Lewis肺癌移植到C57Bl/6J雄性小鼠体内。采用常规方法评估抗肿瘤和抗转移效果。
单次低治疗剂量5mg/kg的C60FAS可抑制移植性恶性肿瘤的生长（抗肿瘤作用）和转移（抗转移作用）：发现肿瘤生长抑制的最大治疗效果为76.5%；发现动物寿命延长22%；转移抑制指数估计为48%。
发现水溶性原始C60富勒烯可有效抑制移植性恶性肿瘤的生长和转移。
