Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
Center for Evidence-Based and Translational Medicine, Wuhan University, Wuhan 430071, P.R. China.
Sci Rep. 2017 Jan 16;7:40554. doi: 10.1038/srep40554.
Although the association between CAG and GGN repeats in the androgen receptor gene and prostate cancer risk has been widely studied, it remains controversial from previous meta-analyses and narrative reviews. Therefore, we performed this meta-analysis to provide more precise estimates with sufficient power. A total of 51 publications with 61 studies for CAG repeats and 14 publications with 16 studies for GGN repeats were identified in the meta-analysis. The results showed that short CAG repeats (<22 repeats) carriers presented an elevated risk of prostate cancer than long CAG repeats (≥22) carriers (OR = 1.31, 95% CI 1.16 to 1.47). Prostate cancer cases presented an average fewer CAG repeats (MD = -0.85, 95% CI -1.28 to -0.42) than controls. Short GGN repeats (≤16) carriers presented an increased risk of prostate cancer than long GGN repeats (>16) carriers (OR = 1.38, 95% CI 1.05 to 1.82). In subgroup analyses, the abovementioned significant association was predominantly observed in Caucasian populations. The meta-analysis showed that short CAG and GGN repeats in androgen receptor gene were associated with increased risk of prostate cancer, especially in Caucasians.
尽管雄激素受体基因中的 CAG 和 GGN 重复序列与前列腺癌风险之间的关联已被广泛研究，但来自先前的荟萃分析和叙述性综述的结果仍存在争议。因此，我们进行了这项荟萃分析，以提供更准确的估计并具有足够的统计效力。在荟萃分析中，共确定了 51 篇关于 CAG 重复的文献和 61 项研究，以及 14 篇关于 GGN 重复的文献和 16 项研究。结果表明，短 CAG 重复（<22 个重复）携带者患前列腺癌的风险高于长 CAG 重复（≥22 个重复）携带者（OR=1.31，95%CI 1.16 至 1.47）。前列腺癌病例的 CAG 重复数平均较少（MD=-0.85，95%CI-1.28 至-0.42）。短 GGN 重复（≤16）携带者患前列腺癌的风险高于长 GGN 重复（>16）携带者（OR=1.38，95%CI 1.05 至 1.82）。在亚组分析中，上述显著关联主要在白种人群中观察到。荟萃分析表明，雄激素受体基因中的短 CAG 和 GGN 重复与前列腺癌风险增加相关，尤其是在白种人群中。
