Audrit Katrin Julia, Delventhal Lucas, Aydin Öznur, Nassenstein Christina
Institute of Anatomy and Cell Biology, Aulweg 123, 35385, Giessen, Germany.
German Center for Lung Research (DZL), Giessen, Germany.
Cell Tissue Res. 2017 Mar;367(3):571-590. doi: 10.1007/s00441-016-2559-7. Epub 2017 Jan 14.
Inflammatory lung diseases are associated with bronchospasm, cough, dyspnea and airway hyperreactivity. The majority of these symptoms cannot be primarily explained by immune cell infiltration. Evidence has been provided that vagal efferent and afferent neurons play a pivotal role in this regard. Their functions can be altered by inflammatory mediators that induce long-lasting changes in vagal nerve activity and gene expression in both peripheral and central neurons, providing new targets for treatment of pulmonary inflammatory diseases.
炎症性肺病与支气管痉挛、咳嗽、呼吸困难和气道高反应性有关。这些症状中的大多数不能主要通过免疫细胞浸润来解释。已有证据表明，迷走神经传出和传入神经元在这方面起关键作用。炎症介质可改变它们的功能，这些介质会在外周和中枢神经元中引起迷走神经活动和基因表达的持久变化，为治疗肺部炎症性疾病提供了新的靶点。
