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笼内转轮跑动减少：一种评估大鼠偏头痛疼痛的可靠且与临床相关的方法。

Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats.

作者信息

Kandasamy Ram, Lee Andrea T, Morgan Michael M

机构信息

Graduate Program in Neuroscience, Washington State University, Pullman, WA, USA.

Washington State University Vancouver, 14204 NE Salmon Creek Ave, Vancouver, WA, 98686, USA.

出版信息

J Headache Pain. 2017 Dec;18(1):5. doi: 10.1186/s10194-017-0721-6. Epub 2017 Jan 13.

DOI:10.1186/s10194-017-0721-6
PMID:28091820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5236037/
Abstract

BACKGROUND

The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can be mimicked in rats. The goal of the present study was to test the hypothesis thatdepression of home cage wheel running is a reliable and clinically relevant method to assess migraine painin rats.

METHODS

Adult female rats were implanted with a cannula to inject allyl isothiocyanate (AITC) onto the dura to induce migraine pain, as has been shown before. Rats recovered from implantation surgery for 8 days in cages containing a running wheel. Home cage wheel running was recorded 23 h a day. AITC and the migraine medication sumatriptan were administered in the hour prior to onset of the dark phase.

RESULTS

Administration of AITC caused a concentration-dependent decrease in wheel running that lasted 3 h. The duration and magnitude of AITC-induced depression of wheel running was consistent following three repeated injections spaced 48 h apart. Administration of sumatriptan attenuated AITC-induced depressionof wheel running when a large dose (1 mg/kg) was administered immediately following AITC administration. Wheel running patterns did not change when sumatriptan was given to naïve rats.

CONCLUSIONS

These data indicate that home cage wheel running is a sensitive, reliable, and clinically relevant method to assess migraine pain in the rat.

摘要

背景

新的抗偏头痛治疗方法的开发受到在实验动物中评估偏头痛疼痛困难的限制。活动减少是少数可在大鼠中模拟的偏头痛诊断标准之一。本研究的目的是检验以下假设：家笼中轮子跑动减少是评估大鼠偏头痛疼痛的一种可靠且与临床相关的方法。

方法

如先前所示，成年雌性大鼠植入套管以将异硫氰酸烯丙酯（AITC）注射到硬脑膜上以诱导偏头痛疼痛。大鼠在装有跑轮的笼子中从植入手术中恢复8天。每天记录23小时的家笼轮子跑动情况。在黑暗期开始前一小时给予AITC和偏头痛药物舒马曲坦。

结果

给予AITC导致轮子跑动呈浓度依赖性减少，持续3小时。在间隔48小时的三次重复注射后，AITC诱导的轮子跑动减少的持续时间和幅度是一致的。在给予AITC后立即给予大剂量（1mg/kg）舒马曲坦可减轻AITC诱导的轮子跑动减少。当给未处理的大鼠给予舒马曲坦时，轮子跑动模式没有改变。

结论

这些数据表明，家笼轮子跑动是评估大鼠偏头痛疼痛的一种敏感、可靠且与临床相关的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/44f4d4c9c87b/10194_2017_721_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/4b930e4689af/10194_2017_721_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/34d9409df57a/10194_2017_721_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/a217bfc54db5/10194_2017_721_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/aac4e10a6a07/10194_2017_721_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/44f4d4c9c87b/10194_2017_721_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/4b930e4689af/10194_2017_721_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/34d9409df57a/10194_2017_721_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/a217bfc54db5/10194_2017_721_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/aac4e10a6a07/10194_2017_721_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2885/5236037/44f4d4c9c87b/10194_2017_721_Fig5_HTML.jpg

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本文引用的文献

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Pharmacol Ther. 2017 Apr;172:151-170. doi: 10.1016/j.pharmthera.2016.12.005. Epub 2016 Dec 2.
2
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Inflamm Res. 2017 Apr;66(4):311-322. doi: 10.1007/s00011-016-1015-1. Epub 2016 Nov 30.
3
Sex differences in the epidemiology, clinical features, and pathophysiology of migraine.
AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization.
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J Headache Pain. 2024 Mar 8;25(1):29. doi: 10.1186/s10194-024-01739-w.
4
PAW, a cost-effective and open-source alternative to commercial rodent running wheels.PAW是一种经济高效且开源的商用啮齿动物跑步轮替代品。
HardwareX. 2023 Dec 12;17:e00499. doi: 10.1016/j.ohx.2023.e00499. eCollection 2024 Mar.
5
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J Neurotrauma. 2023 Dec;40(23-24):2654-2666. doi: 10.1089/neu.2022.0305. Epub 2023 Sep 19.
6
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7
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Lancet Neurol. 2017 Jan;16(1):76-87. doi: 10.1016/S1474-4422(16)30293-9. Epub 2016 Nov 9.
4
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5
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6
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7
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8
Neurovascular contributions to migraine: Moving beyond vasodilation.神经血管因素在偏头痛中的作用：超越血管舒张的研究
Neuroscience. 2016 Dec 3;338:130-144. doi: 10.1016/j.neuroscience.2016.06.012. Epub 2016 Jun 14.
9
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J Pharmacol Toxicol Methods. 2016 Jul-Aug;80:43-50. doi: 10.1016/j.vascn.2016.04.004. Epub 2016 Apr 9.