精氨酸-脯氨酸-甘氨酸-脯氨酸肽在强迫游泳试验诱发大鼠情绪应激期间的抗血栓保护作用

Antithrombotic Protective Effects of Arg-Pro-Gly-Pro Peptide during Emotional Stress Provoked by Forced Swimming Test in Rats.

作者信息

Grigor'eva M E, Lyapina L A

机构信息

B. A. Kudryashov Laboratory of Blood Protective System, Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2017 Jan;162(3):300-302. doi: 10.1007/s10517-017-3599-z. Epub 2017 Jan 14.

DOI:10.1007/s10517-017-3599-z

PMID:28091900

Abstract

Blood coagulation was enhanced and all factors (total, enzyme, and non-enzyme) of the fibrinolytic system were suppressed in rats in 60 min after forced swimming test. Argininecontaining tetrapeptide glyproline Arg-Pro-Gly-Pro administered prior to this test activated fibrinolysis and prevented hypercoagulation. Administration of this peptide in 5 min after swimming test also enhanced anticoagulant, fibrinolytic, and antithrombotic activity of the blood. Therefore, glyproline Arg-Pro-Gly-Pro exerted both preventive and curative effects on the hemostasis system and prevented enhancement of blood coagulation provoked by emotional stress modeled by forced swimming test.

摘要

强迫游泳试验后60分钟，大鼠的血液凝固增强，纤维蛋白溶解系统的所有因子（总因子、酶因子和非酶因子）均受到抑制。在此试验前给予含精氨酸的四肽甘脯氨酸（Arg-Pro-Gly-Pro）可激活纤维蛋白溶解并预防高凝状态。游泳试验后5分钟给予该肽也可增强血液的抗凝、纤维蛋白溶解和抗血栓活性。因此，甘脯氨酸（Arg-Pro-Gly-Pro）对止血系统具有预防和治疗作用，并可预防由强迫游泳试验模拟的情绪应激所引发的血液凝固增强。