Vyshtakalyuk A B, Nazarov N G, Zobov V V, Abdulkhakov S R, Minnekhanova O A, Semenov V E, Galyametdinova I V, Cherepnev G V, Reznik V S
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, Kazan, Russia.
Kazan (Volga Region) Federal University, Kazan, Russia.
Bull Exp Biol Med. 2017 Jan;162(3):340-342. doi: 10.1007/s10517-017-3610-8. Epub 2017 Jan 14.
Hepatoprotective properties of a new pyrimidine derivative - L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
基于Xymedon合成的一种新型嘧啶衍生物——L-抗坏血酸1-(2-羟乙基)-4,6-二甲基-1,2-二氢嘧啶-2-酮的肝脏保护特性，在暴露于四氯化碳的白鼠身上进行了评估。与对照组相比，在暴露于四氯化碳之前给予所研究的化合物，可减少生化参数与参考值的偏差以及肝脏结构和形态变化的严重程度。所研究化合物的肝脏保护特性比Xymedon更显著。
