Amstein R, Bühler F R, Beretta-Piccoli C, Bertel O, Brunner H R, Follath F, Heer K, Reutter F, Vallotton M B
University Hospital, Basel, Switzerland.
J Hypertens. 1989 Aug;7(8):619-24. doi: 10.1097/00004872-198908000-00004.
The effects of ketanserin on blood pressure and well-being were investigated in 188 patients, aged 41-82 years, with mild to moderate essential hypertension. At entry, 107 were untreated, 42 were taking the diuretic combination hydrochlorothiazide (50 mg/day) plus amiloride (5 mg/day) and another 39 were taking the beta-blocker atenolol (100 mg/day). A single-blind, 4-week placebo run-in period was followed by 12 weeks' oral ketanserin treatment at 20 or 40 mg twice a day. This regimen significantly reduced systolic and diastolic blood pressures in each group. Response rates were greater in patients aged over 60 years. Compared with placebo, sleep disturbances, daytime fatigue and overall weakness decreased during ketanserin treatment (P less than 0.05 for all), but the incidence of dry mouth and stuffy nose increased. In patients older than 60 years there was a greater reduction of complaints than in younger patients. Ketanserin proved effective and well tolerated, improving peripheral circulatory symptomatology, particularly in older patients and those with a good blood pressure response.
在188例年龄为41 - 82岁的轻度至中度原发性高血压患者中，研究了酮色林对血压和健康状况的影响。入组时，107例未接受治疗，42例正在服用氢氯噻嗪（50毫克/天）加阿米洛利（5毫克/天）的利尿剂组合，另外39例正在服用β受体阻滞剂阿替洛尔（100毫克/天）。经过为期4周的单盲安慰剂导入期后，进行为期12周的口服酮色林治疗，剂量为每日两次，每次20或40毫克。该治疗方案显著降低了每组患者的收缩压和舒张压。60岁以上患者的有效率更高。与安慰剂相比，酮色林治疗期间睡眠障碍、日间疲劳和全身乏力有所减轻（均P<0.05），但口干和鼻塞的发生率增加。60岁以上患者的症状改善程度大于年轻患者。酮色林被证明有效且耐受性良好，可改善外周循环症状，尤其是在老年患者和血压反应良好的患者中。
